Background Asthma is a complex disease characterized by hyperresponsiveness,
obstruction and inflammation of the airways. To date, several studies using different …

In the era of genome-wide association (GWA) studies, delineating pathogenic asthma
genetic pathways has provided both challenges and opportunities. Initial GWA studies on …

Asthma is a complex disease determined by the interaction between genetic and
environmental factors. The heritability of asthma is estimated to be more than 50%. The …

For the past two decades, a huge number of genetic studies have been conducted to identify
the genetic variants responsible for asthma risk. Several types of genetic and genomic …

Asthma is a complex syndrome leading to the easily recognizable clinical feature of
wheezing. This is believed to be caused by inflammation, constriction of the airway smooth …

Genetic studies of asthma have revealed that there is considerable heritability to the
phenotype. An extensive history of candidate-gene studies has identified a long list of genes …

Asthma is a pulmonary disease characterized by increased bronchial responsiveness to a
variety of stimuli. It is the most common chronic disease of childhood and the most frequent …

Asthma and allergic diseases are complex conditions caused by a combination of genetic
and environmental factors. More than 100 genes have been associated with asthma and …

Epidemiological and twin studies have demonstrated that asthma is under genetic and
environmental influences. Numerous candidate gene association studies as well as genome …

The astounding number of genetic variants revealed in the 15 years of genome-wide
association studies of asthma has not kept pace with the goals of translational genomics …