Abstract Perturbed Endoplasmic Reticulum (ER) calcium (Ca 2+) homeostasis emerges as a
central player in Alzheimer disease (AD). Accordingly, different studies have reported …

Disruption of intracellular calcium homeostasis precedes the neurodegeneration that occurs
in Alzheimer disease (AD). Of the many neuronal calcium-regulating proteins, we focused …

Research into the early impacts of Alzheimer's disease (AD) on synapse function is one of
the most promising approaches to finding a treatment. In this context, we have recently …

Ryanodine receptors (RyRs) are intracellular calcium-release channels found on the
endoplasmic reticulum of all cells. All three RyR isoforms, RyR1–3, are expressed in the …

Alteration of ryanodine receptor (RyR)-mediated calcium (Ca 2+) signaling has been
reported in Alzheimer disease (AD) models. However, the molecular mechanisms …

Dysregulated endoplasmic reticulum (ER) calcium (Ca2+) signaling is reported to play an
important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca2+ release …

The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …

Intracellular Ca2+ dysregulation is an underlying component of Alzheimer's disease (AD)
pathophysiology, and recent evidence implicates the ryanodine receptor (RyR) in the …

Neuronal hyperactivity is an early primary dysfunction in Alzheimer's disease (AD) in
humans and animal models, but effective neuronal hyperactivity-directed anti-AD …

The cellular pathology of Alzheimer's disease is progressive and protracted leading
eventually to considerable neuronal death. The underlying mechanisms of the pathology are …