Alzheimer's disease (AD) is the most prevalent form of dementia among the elderly and is a
complex disorder that involves altered proteolysis, oxidative stress and disruption of ion …

Hydrogen peroxide, which stimulates ERK phosphorylation and synaptic plasticity in
hippocampal neurons, has also been shown to stimulate calcium release in muscle cells by …

Cellular Ca2+ signalling is an important factor in the control of neuronal metabolism and
electrical activity. Although the roles of Ca2+-release channels are well established for …

The amyloid‐beta peptides (Aβ) are produced in excess in Alzheimer's disease (AD) and
may contribute to neuronal dysfunction and degeneration. This study provides strong …

Although anything that changes spatiotemporally could be a signal, cells, particularly
neurons, precisely manipulate calcium ion (Ca2+) to transmit information. Ca2+ …

Evidence accumulated over more than two decades has implicated Ca2+ dysregulation in
brain aging and Alzheimer's disease (AD), giving rise to the Ca2+ hypothesis of brain aging …

Perturbed neuronal Ca 2+ homeostasis is implicated in age-related cognitive impairment
and Alzheimer's disease (AD). With advancing age, neurons encounter increased oxidative …

Calcium is one of the most important intracellular messengers in the brain, being essential
for neuronal development, synaptic transmission and plasticity, and the regulation of various …

Alzheimer's disease (AD)-linked presenilin (PS) mutations result in pronounced
endoplasmic reticulum calcium disruptions that occur before detectable histopathology and …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most
common cause of dementia among aged people whose population is rapidly increasing. AD …