Cerebral ischemia stimulates Ca2+ influx and thus increases neuronal intracellular free
[Ca2+]. Using a rat model of cerebral ischemia without recirculation, we tested whether …

The release of Ca2+ from intracellular stores mediated by ryanodine receptors (RyR) Ca2+
release channels is essential for striated muscle contraction and contributes to diverse …

Introduction• Dysregulation of Ca2+ homeostasis in AD‐Aβ accumulation causes Ca2+
dyshomeostasis‐Ca2+ dyshomeostasis increases Aβ production• Presenilins and Ca2+ …

Studies with in‐vitro‐cultured neurons treated with amyloid‐β (Aβ) peptides demonstrated
neuronal loss by apoptosis that is due, at least in part, to the perturbation of intracellular …

Endoplasmic reticulum (ER) appears to be a focal point for alterations that result in neuronal
dysfunction and death in Alzheimer's disease (AD). Aberrant proteolytic processing and/or …

Neurodegeneration in Alzheimer's disease (AD) has been linked to intracellular
accumulation of misfolded proteins and dysregulation of intracellular Ca2+. In the current …

More than one century ago “a peculiar disorder of the cerebral cortex” was noticed in a
middle‐aged patient who had been affected by dementia in the last years of his life. The …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the elderly that is
characterized by memory loss. Neuropathologically, the AD brain is marked by an increased …

Dynamic regulation of the intracellular Ca2+ concentration is crucial for various neuronal
functions such as synaptic transmission and plasticity, and gene expression. Ryanodine …

The relationship between altered metabolism of the amyloid-β precursor protein (APP) and
Alzheimer's disease is well established but the physiological roles of APP still remain …