Although the calcium-sensing receptor (CaSR) is expressed by all types of nerve cells in
widespread areas of the human central nervous system (CNS), so far its roles in brain …

The most accredited (and fashionable) hypothesis of the pathogenesis of Alzheimer Disease
(AD) sees accumulation of β-amyloid protein in the brain (in both soluble and insoluble …

Presenilin (PS) plays a central role in the pathogenesis of Alzheimer's disease, and loss of
PS causes progressive memory impairment and age-related neurodegeneration in the …

The progress we have made in understanding Alzheimer's disease (AD) pathogenesis has
led to the identification of several novel pathways and potential therapeutic targets. Rho …

Alzheimer's disease (AD) is the disease of lost memories. Synaptic loss is a major reason for
memory defects in AD. Signaling pathways involved in memory loss in AD are under intense …

Genetic mutations in ryanodine receptors (RyRs), Ca2+-release channels in the
sarcoplasmic reticulum essential for muscle contractions, cause various skeletal muscle and …

Ryanodine receptors (RyRs) regulate contractility in resistance-size cerebral artery smooth
muscle, yet their molecular identity, subcellular location, and phenotype in this tissue remain …

Excitation-contraction coupling involves the faithful conversion of electrical stimuli to
mechanical shortening in striated muscle cells, enabled by the ubiquitous second …

Calcium signaling critical to neural functions is mediated through Ca2+ channels localized
on both the plasma membrane and intracellular organelles such as endoplasmic reticulum …

Alzheimer's disease (AD) and aging result in impaired ability to store memories, but the
cellular mechanisms responsible for these defects are poorly understood. Presenilin 1 (PS1) …