Background In cancer therapy, molecularly targeted agents have the potential to maximize
antitumor efficacy while minimizing treatment-related toxicity. However, these agents may …

Folates are B vitamins that function in one-carbon metabolism. Folate receptors are one of
three major types of folate transporters. The folate receptors FOLR1 and FOLR2 are …

Folate is a B vitamin necessary for basic biological functions, including rapid cell turnover
occurring in cancer cell proliferation. Though the role of folate as a causative versus …

The membrane-bound folate receptor (FR) is overexpressed on a wide range of human
cancers, such as those originating in ovary, lung, breast, endometrium, kidney and brain …

The discovery of the high-affinity, high-specificity folate receptor in mamalian kidney cells,
coupled with the ability of folate to enter cells by folate receptor-mediated endocytosis and …

This review surveys soluble Folate Receptors (FOLRs) in humans. FOLR1 and FOLR2 are
equipped with cellular glycosylphosphatidylinositol (GPI) anchors. FOLR1 is secreted from …

The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety
of cancers. The current development of folate-targeted cancer therapies has created the …

Cancer therapies that exploit targeting ligands to deliver attached cytotoxic drugs selectively
to malignant cells are currently receiving significant attention. While antibody-targeted drugs …

The covalent attachment of the vitamin folic acid to almost any molecule yields a conjugate
that can be endocytosed into folate receptor-bearing cells. Because folate receptors are …

Objectives Ovarian cancer is the most lethal gynecological malignancy in North America.
Although survival rates are high when the disease is diagnosed at an early stage, this …