Folate receptor α (FRα) is a membrane‐bound protein with high affinity for binding and
transporting physiologic levels of folate into cells. Folate is a basic component of cell …

Introduction: Folate receptor− α (FR− α) has been established as a membrane marker for
ovarian cancer. In addition, it is frequently overexpressed in other major types of epithelial …

Targeted delivery via selective cellular markers can potentially increase the efficacy and
reduce the toxicity of therapeutic agents. The folate receptor (FR) has two glycosyl …

Folate receptor-targeted cancer therapies constitute a promising treatment for the
approximately one third of human cancers that overexpress the folate receptor (FR) …

The cell-membrane folate receptor is a potential molecular target for tumor-selective drug
delivery, including delivery of radiolabeled folate–chelate conjugates for diagnostic imaging …

De novo nucleotide synthesis and one-carbon metabolism require the vitamin folic acid (MW
441, Fig. 1), which cannot be synthesized by mammalian cells. Therefore, cellular uptake of …

In order to avoid the toxicities associated with prescription drug use today, we have explored
novel methods for delivering drugs selectively to pathologic cells, thereby avoiding the …

A number of folate receptor (FR) targeted small molecular drugs and monoclonal antibodies
have been introduced into clinical trials to treat FR positive cancers. Because the therapeutic …

Overexpression of folate receptors (FRs) on different tumor types (eg, ovarian, lung) make
FRs attractive in vivo targets for directed diagnostic/therapeutic agents. Currently, no …

The folate receptor (FR) is a potentially useful biological target for the management of many
human cancers. This membrane protein binds extracellular folates with very high affinity …