Background Whether there is a mechanistic link between FOLR1 and response to cisplatin
has not been extensively examined. In this study, we determine the expression of FOLR1 in …

The folate receptor (FR) is expressed in many tumor types, among those ovarian and lung
cancer. Due to the high FR affinity of folic acid, it has been used for targeting of FR-positive …

The distinct roles of protein isoforms in cancer are becoming increasingly evident. FRα and
FRβ, two major isoforms of the folate receptor family, generally have different cellular …

Neoplasias pose a significant threat to aging society, underscoring the urgent need to
overcome the limitations of traditional chemotherapy through pioneering strategies …

A new transplantable ovarian tumor model is presented using a novel folate receptor (FR)
positive, murine ovarian cancer cell line that emulates the human disease and induces …

Background In this retrospective study we evaluated the respective correlations and clinical
relevance of FOLR1 mRNA expression, FOLR1 promoter specific methylation and global …

Introduction Non-invasive imaging techniques such as positron emission tomography (PET)
are extremely important for cancer detection and characterization especially for difficult to …

Folate receptors including folate receptor α (FRα) are overexpressed in up to 90% of ovarian
cancers. Ovarian cancers overexpressing FRα often exhibit high degrees of drug resistance …

Folate uptake in epithelial ovarian cancer (EOC) involves the reduced folate carrier (RFC)
and the proton-coupled folate transporter (PCFT), both facilitative transporters and folate …

OBJECTIVE: Based on its expression profile, folate receptor alpha (FRA) is an attractive
candidate for targeted diagnostics and therapeutics. However, applicability of these agents …