Abstract HLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound
peptides in endocytic compartments and stabilizes empty MHCII molecules. Crystal …

The peptide editor HLA-DM (DM) catalyzes the exchange of peptides bound to MHC class II
molecules within antigen presenting cells by generating a “peptide-receptive” MHC class II …

The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major
histocompatibility (MHC) class II molecules during antigen processing; however, the …

The mechanism by which HLA-DM (DM) promotes exchange of peptides bound to HLA-DR
(DR) is still unclear. We have shown that peptide interaction with DR1 can be considered a …

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …

Recently, crystal structures of key complexes in antigen presentation have been reported.
HLA-DM functions in antigen presentation by catalyzing dissociation of an invariant chain …

DM facilitates formation of high affinity complexes of peptide–major histocompatibility
complex (MHC) by release of class II MHC–associated invariant chain peptide (CLIP). This …

Antigenic peptide loading of major histocompatibility complex class II molecules is
enhanced by lysosomal pH and catalyzed by the HLA-DM molecule. The physical …

Considerable progress has been made in the field of major histocompatibility complex
(MHC) class II-restricted antigen presentation. The analysis of mutant cell lines defective in …

HLA-DM serves a critical function in the loading and editing of peptides on MHC class II
(MHCII) molecules. Recent data showed that the interaction cycle between MHCII molecules …