Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides
Abstract HLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound
peptides in endocytic compartments and stabilizes empty MHCII molecules. Crystal …
peptides in endocytic compartments and stabilizes empty MHCII molecules. Crystal …
HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1
K Narayan, KW Su, CL Chou, S Khoruzhenko… - Molecular …, 2009 - Elsevier
The peptide editor HLA-DM (DM) catalyzes the exchange of peptides bound to MHC class II
molecules within antigen presenting cells by generating a “peptide-receptive” MHC class II …
molecules within antigen presenting cells by generating a “peptide-receptive” MHC class II …
HLA-DM targets the hydrogen bond between the histidine at position β81 and peptide to dissociate HLA-DR–peptide complexes
The peptide editor HLA-DM (DM) mediates exchange of peptides bound to major
histocompatibility (MHC) class II molecules during antigen processing; however, the …
histocompatibility (MHC) class II molecules during antigen processing; however, the …
Cutting Edge: HLA-DM–Mediated Peptide Exchange Functions Normally on MHC Class II–Peptide Complexes That Have Been Weakened by Elimination of a …
A Ferrante, J Gorski - The journal of immunology, 2010 - journals.aai.org
The mechanism by which HLA-DM (DM) promotes exchange of peptides bound to HLA-DR
(DR) is still unclear. We have shown that peptide interaction with DR1 can be considered a …
(DR) is still unclear. We have shown that peptide interaction with DR1 can be considered a …
Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide
L Yin, P Trenh, A Guce, M Wieczorek, S Lange… - Journal of Biological …, 2014 - ASBMB
HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …
presentation by a mechanism that remains unclear and controversial. Here, we investigated …
Mechanisms of peptide repertoire selection by HLA-DM
Recently, crystal structures of key complexes in antigen presentation have been reported.
HLA-DM functions in antigen presentation by catalyzing dissociation of an invariant chain …
HLA-DM functions in antigen presentation by catalyzing dissociation of an invariant chain …
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II
CL Chou, S Sadegh-Nasseri - The Journal of experimental medicine, 2000 - rupress.org
DM facilitates formation of high affinity complexes of peptide–major histocompatibility
complex (MHC) by release of class II MHC–associated invariant chain peptide (CLIP). This …
complex (MHC) by release of class II MHC–associated invariant chain peptide (CLIP). This …
Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH
HJ Ullrich, K Döring, U Grüneberg… - Proceedings of the …, 1997 - National Acad Sciences
Antigenic peptide loading of major histocompatibility complex class II molecules is
enhanced by lysosomal pH and catalyzed by the HLA-DM molecule. The physical …
enhanced by lysosomal pH and catalyzed by the HLA-DM molecule. The physical …
How HLA-DM affects the peptide repertoire bound to HLA-DR molecules
AB Vogt, H Kropshofer, GJ Hämmerling - Human immunology, 1997 - Elsevier
Considerable progress has been made in the field of major histocompatibility complex
(MHC) class II-restricted antigen presentation. The analysis of mutant cell lines defective in …
(MHC) class II-restricted antigen presentation. The analysis of mutant cell lines defective in …
The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway
MSED Schulze, KW Wucherpfennig - Current opinion in immunology, 2012 - Elsevier
HLA-DM serves a critical function in the loading and editing of peptides on MHC class II
(MHCII) molecules. Recent data showed that the interaction cycle between MHCII molecules …
(MHCII) molecules. Recent data showed that the interaction cycle between MHCII molecules …
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