An improved understanding of pathogenic pathways in AKI may identify novel therapeutic
approaches. Previously, we conducted unbiased liquid chromatography-tandem mass …

Mitogen-activated protein kinases (MAP kinases) are functionally connected kinases that
regulate key cellular process involved in kidney disease such as all survival, death …

Abstract Background/Aims: Kidney injury molecule-1 (KIM-1) is highly expressed in renal
tubular cells after injury and is usually regarded as an early biomarker of acute kidney injury …

Elevated mitogen-activated protein kinase p38 (p38 MAPK) signaling has been implicated in
various experimental and human glomerulopathies, and its inhibition has proven beneficial …

We investigated the role of apoptosis signal-regulating kinase 1 (ASK1) in
ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Blood urea nitrogen (BUN) and …

Mitogen activated protein kinases (MAPKs) are intracellular signal transduction molecules,
which connect cell‐surface receptor signals to intracellular processes. MAPKs regulate a …

Ischemic acute kidney injury is a serious untreatable condition. Activation of the G protein
α12 (Gα12) subunit by reactive oxygen species is a major cause of tissue damage during …

Apoptosis signal‐regulating kinase 1 (ASK1) is a member of the mitogen‐activated protein
kinase (MAP3K) family which acts as an upstream regulator for the activation of p38 MAPK …

Abstract TGFβ1/Smad, Wnt/β‐catenin and snail1 are preferentially activated in renal tubular
epithelia after injury, leading to epithelial–mesenchymal transition (EMT). The stress …

We have reported that preconditioning renal tubular cells (RTCs) with A-769662 [a
pharmacological activator of AMP-activated protein kinase (AMPK)] reduces apoptosis of …