The use of iron as an enzymatic cofactor is pervasive in biological systems. Consequently
most living organisms, including pathogenic bacteria, require iron to survive and replicate …

The unique redox potential of iron makes it an ideal cofactor in diverse biochemical
reactions. Iron is therefore vital for the growth and proliferation of nearly all organisms …

Pathogenic Gram-positive bacteria encounter many obstacles in route to successful invasion
and subversion of a mammalian host. As such, bacterial species have evolved clever ways …

Iron is frequently a growth-limiting nutrient due to its propensity to interact with oxygen to
form insoluble precipitates and, therefore, biological systems have evolved specialized …

Staphylococcus aureus pathogenesis is significantly influenced by the iron status of the host.
However, the regulatory impact of host iron sources on S. aureus gene expression remains …

Staphylococcus aureus is able to grow in the presence of extremely low iron concentrations
(0.04 µM). In iron-limiting conditions, this species develops alternative metabolic strategies …

Despite the ability of staphylococci to grow in iron-restricted conditions in vivo, their iron
requirements and the mechanisms possessed by them for the uptake of iron are poorly …

Cell-wall sorted proteins of the Staphylococcus aureus iron-regulated surface determinant
system bind human hemoproteins, remove the heme molecule, and transport heme through …

Staphylococci grow and cause infection under the iron-restricted conditions found in vivo.
They therefore must possess mechanisms to obtain iron for metabolism from this …

The availability of iron plays a critical role in host-parasite relations. Microbial pathogens
cannot replicate without acquiring iron from their vertebrate hosts, and several strategies of …