Bacterial iron metabolism in infection and immunity

JJ Bullen, HJ ROGERS, E Griffiths - Microbial iron metabolism, 1974 - Elsevier
Publisher Summary This chapter discusses bacterial iron metabolism in infection and
immunity. The injection of iron compounds can enhance the virulence of certain bacteria …

Iron-Regulated Biofilm Formation in Staphylococcus aureus Newman Requires ica and the Secreted Protein Emp

M Johnson, A Cockayne, JA Morrissey - Infection and immunity, 2008 - Am Soc Microbiol
Staphylococcus aureus biofilm formation is induced in iron-restricted growth conditions in
vitro. In this study, we showed that Emp and Eap play important roles in low-iron-induced …

Passage of Heme-Iron Across the Envelope of Staphylococcus aureus

SK Mazmanian, EP Skaar, AH Gaspar, M Humayun… - Science, 2003 - science.org
The cell wall envelope of Gram-positive pathogens functions as a scaffold for the attachment
of virulence factors and as a sieve that prevents diffusion of molecules. Here the isd genes …

Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron

PR Young, SH Yu, CM Hwa, BY Hoon… - Journal of …, 2005 - koreascience.kr
Staphylococcus aureus is known to be capable of utilizing transferrin-bound iron, via both
siderophoreand transferrin-binding protein (named IsdA)-mediated iron-acquisition systems …

TCA cycle activity in Staphylococcus aureus is essential for iron‐regulated synthesis of staphyloferrin A, but not staphyloferrin B: the benefit of a second citrate …

JR Sheldon, CL Marolda… - Molecular …, 2014 - Wiley Online Library
S taphylococcus aureus elaborates two citrate‐containing siderophores, staphyloferrin A
(SA) and staphyloferrin B (SB), that enhance growth under iron‐restriction, yet …

Transferrin binding in Staphylococcus aureus: involvement of a cell wall‐anchored protein

JM Taylor, DE Heinrichs - Molecular microbiology, 2002 - Wiley Online Library
The ability to gain access to iron is pivotal for bacterial pathogens during infection. Although
much is known about iron acquisition systems in Gram‐negative bacteria, comparatively …

Key players in the regulation of iron homeostasis at the host-pathogen interface

I Ullah, M Lang - Frontiers in Immunology, 2023 - frontiersin.org
Iron plays a crucial role in the biochemistry and development of nearly all living organisms.
Iron starvation of pathogens during infection is a striking feature utilized by a host to quell …

Iron thievery

J Barasch, K Mori - Nature, 2004 - nature.com
Iron thievery | Nature Skip to main content Thank you for visiting nature.com. You are using a
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The battle for iron in enteric infections

A Sousa Gerós, A Simmons, H Drakesmith… - …, 2020 - Wiley Online Library
Iron is an essential element for almost all living organisms, but can be extremely toxic in high
concentrations. All organisms must therefore employ homeostatic mechanisms to finely …

Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response

W Neumann, A Gulati, EM Nolan - Current opinion in chemical biology, 2017 - Elsevier
Highlights•Staphylopine is a metallophore that Staphylococcus aureus deploys to acquire
first-row transition metals.•The protein SbnI provides a link between heme uptake and …