Multi-functional nanocomplex codelivery of Trp2 and R837 to activate melanoma-specific immunity

Z Ji, Z Tan, M Li, J Tao, E Guan, J Du, Y Hu - International Journal of …, 2020 - Elsevier
Antigen-adjuvant combination could induce a protective and long-lasting anti-tumor immune
response. However, exploiting system which could co-deliver melanoma antigen peptide …

Synergistically enhanced cancer immunotherapy by combining protamine-based nanovaccine with PD-L1 gene silence nanoparticle

M Jiang, W Chen, Y Sun, J Zeng, L Ma, J Gong… - International Journal of …, 2023 - Elsevier
Tumor vaccine has brought a new dawn for cancer immunotherapy, but disillusionary
therapeutic outcomes have been achieved due to the inefficient in vivo vaccine delivery …

Targeting Tumor-Associated Macrophages with the Immune-Activating Nanomedicine for Achieving Strong Antitumor Activity with Rapid Clearance from the Body

Y Ota, R Inagaki, Y Takanashi, H Uemachi… - ACS …, 2024 - ACS Publications
Toll-like receptors (TLRs) are a class of pattern recognition receptors (PRRs) crucial for the
detection of infections and activation of downstream signaling pathways that lead to the …

The mechanisms of immune-chemotherapy with nanocomplex codelivery of pTRP-2 and adjuvant of paclitaxel against melanoma

Z Ji, J Xu, M Li, H Wang, B Xu, Y Yang… - Drug Development and …, 2021 - Taylor & Francis
Melanoma accounts for the highest proportion of all skin cancer deaths. Immune-
chemotherapy has transformed anti-melanoma therapy and is a preferred first-line …

Supramolecular prodrug nanovectors for active tumor targeting and combination immunotherapy of colorectal cancer

X Hu, B Hou, Z Xu, M Saeed, F Sun, Z Gao… - Advanced …, 2020 - Wiley Online Library
Immunotherapy aiming to harness the exquisite power of the immune system has emerged
as a crucial part of clinical cancer management. However, only a subset of cancer patients …

Co-delivery of Interleukin-12 and doxorubicin loaded Nano-delivery system for enhanced immunotherapy with polarization toward M1-type Macrophages

T Li, Z Liu, X Fu, Y Chen, S Zhu, J Zhang - European Journal of …, 2022 - Elsevier
Chemo-immunotherapy has gained increasing attention as one of the most promising
combination therapy strategies to battle cancer. In this study, the therapeutic nanoparticles …

[HTML][HTML] Dual-responsive nanovaccine for cytosolic delivery of antigens to boost cellular immune responses and cancer immunotherapy

Y Sui, J Li, J Qu, T Fang, H Zhang, J Zhang… - Asian Journal of …, 2022 - Elsevier
Cancer vaccine contributing to the success of the treatment and prevention of tumors has
attracted a huge attention as a strategy for tumor immunotherapy in recent years. A major …

Supermolecular nanovehicles co-delivering TLR7/8-agonist and anti-CD47 siRNA for enhanced tumor immunotherapy

T Shang, X Yu, Y Gu, R Du, Y Cai, Y Li, G Zheng… - International Journal of …, 2023 - Elsevier
Cancer immunotherapy is the most promising method for tumor therapy in recent years,
among which the macrophages play a critical role in the antitumor immune response …

Nanovaccine based on a protein-delivering dendrimer for effective antigen cross-presentation and cancer immunotherapy

J Xu, H Wang, L Xu, Y Chao, C Wang, X Han, Z Dong… - Biomaterials, 2019 - Elsevier
Cancer vaccines for prevention and treatment of tumors have attracted tremendous interests
as a type of cancer immunotherapy strategy. A major challenge in achieving robust T-cell …

[HTML][HTML] Low molecular weight heparin-coated and dendrimer-based core-shell nanoplatform with enhanced immune activation and multiple anti-metastatic effects for …

C Xia, S Yin, S Xu, G Ran, M Deng, L Mei, X Tang… - Theranostics, 2019 - ncbi.nlm.nih.gov
High-efficiency treatment for tumor is not easy to achieve owing to the existence of
metastasis, which remains the arch-criminal of most tumor deaths. Conventional …