[HTML][HTML] DAP‐kinase is a Ca2+/calmodulin‐dependent, cytoskeletal‐associated protein kinase, with cell death‐inducing functions that depend on its catalytic activity

O Cohen, E Feinstein, A Kimchi - The EMBO journal, 1997 - embopress.org
DAP‐kinase was initially identified as a gene whose anti‐sense‐mediated reduced
expression protected HeLa cells from interferon‐γ‐induced programmed cell death. It was …

DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer

O Cohen, A Kimchi - Cell Death & Differentiation, 2001 - nature.com
DAP-kinase is a pro-apoptotic Ca 2+ calmodulin-regulated serine/threonine kinase that
participates in a wide array of apoptotic systems initiated by interferon-γ, TNF-α, activated …

The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases

G Shohat, G Shani, M Eisenstein, A Kimchi - Biochimica et Biophysica Acta …, 2002 - Elsevier
DAP-kinase (DAPk) is a Ca2+/calmodulin (CaM)-regulated Ser/Thr kinase that functions as
a positive mediator of programmed cell death. It associates with actin microfilament and has …

Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase

JC Kuo, JR Lin, JM Staddon, H Hosoya… - Journal of cell …, 2003 - journals.biologists.com
Death-associated protein kinase (DAP kinase) is a proapoptotic, calcium/calmodulin-
dependent serine/threonine kinase. Here, we report that DAP kinase phosphorylates the …

DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals

WJ Wang, JC Kuo, CC Yao, RH Chen - The Journal of cell biology, 2002 - rupress.org
Death-associated protein kinase (DAP-kinase) is a calcium/calmodulin-dependent
serine/threonine kinase, and participates in various apoptosis systems. However, its …

DAP-kinase-mediated morphological changes are localization dependent and involve myosin-II phosphorylation

S Bialik, AR Bresnick, A Kimchi - Cell Death & Differentiation, 2004 - nature.com
DAP-kinase (DAPk) is a Ser/Thr kinase that regulates cytoplasmic changes associated with
programmed cell death. It is shown here that a GFP–DAPk fusion, which partially localized to …

Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity

T Kawai, F Nomura, K Hoshino, NG Copeland… - Oncogene, 1999 - nature.com
We have identified and characterized a new calcium/calmodulin (Ca 2+/CaM) dependent
protein kinase termed death-associated protein kinase 2 (DAPK2) that contains an N …

DAP kinase links the control of apoptosis to metastasis

B Inbal, O Cohen, S Polak-Charcon, J Kopolovic… - Nature, 1997 - nature.com
DAP kinase is a new type of calcium/calmodulin-dependent enzyme that phosphorylates
serine/threonine residues on proteins. Its structure contains ankyrin repeats and the …

A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity

T Raveh, H Berissi, M Eisenstein… - Proceedings of the …, 2000 - National Acad Sciences
Death-associated protein kinase (DAP-kinase) is a Ca+ 2/calmodulin-regulated
serine/threonine kinase with a multidomain structure that participates in apoptosis induced …

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

JL Kissil, E Feinstein, O Cohen, PA Jones, YC Tsai… - Oncogene, 1997 - nature.com
DAP-kinase is a novel calmodulin dependent serine/threonine kinase that carries ankyrin
repeats and the death domain. It was recently isolated, by a functional selection approach of …