Background The presence of antibodies to aquaporin-4 (AQP4) has been identified as a key
characteristic of neuromyelitis optica spectrum disorder (NMOSD), an autoimmune …

Objective Antibodies against water channel protein aquaporin 4 (AQP4) in astrocytes play a
role in the etiology and physiopathology of neuromyelitis optica (NMO); detection of this …

Background Neuromyelitis optica spectrum disorders (NMOSD) are severe central nervous
system inflammatory demyelinating disorders (CNS IDD) characterized by monophasic or …

NMO‐I g G against aquaporin‐4 (AQP 4) is a specific marker for neuromyelitis optica (NMO).
We evaluated the performance of different NMO‐I g G detecting methods. In 124 sera (from …

Objective To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies
and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum …

Objective Determine the utility of aquaporin 4 IgG (AQP4-IgG) testing (live cell-based assay)
for Neuromyelitis Optica Spectrum Disorders (NMOSD). Methods We included Mayo Clinic …

Background Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune
disease associated with a serological antibody to aquaporin-4 (AQP4) detectable in up to …

Background and Purpose The detection of aquaporin 4-IgG (AQP4-IgG) is now a critical
diagnostic criterion for neuromyelitis optica spectrum disorder (NMOSD). To evaluate the …

Abstract Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with
highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG) …

Introduction Neuromyelitis optica spectrum disorder (NMOSD) is characterized by the
presence of serum anti-aquaporin 4 (AQP4) antibody. However, the significance of changes …