[HTML][HTML] Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers
J Yun, SH Song, J Park, HP Kim, YK Yoon, KH Lee… - Laboratory …, 2012 - Elsevier
Epiregulin (EREG) induces cell growth by binding to the epidermal growth factor receptor
(EGFR). Expression of EREG affects sensitivity to cetuximab a chimeric monoclonal antibody …
(EGFR). Expression of EREG affects sensitivity to cetuximab a chimeric monoclonal antibody …
Clinical significance of EREG gene expression in gastric cancer tissue after curative surgery
H Suematsu, I Hashimoto, Y Hiroshima… - Anticancer …, 2022 - ar.iiarjournals.org
Background/Aim: Epiregulin (EREG) is a ligand of the epidermal growth factor receptor
(EGFR) and promotes tumour progression mainly by stimulating the EGF pathway. We …
(EGFR) and promotes tumour progression mainly by stimulating the EGF pathway. We …
Elevated epiregulin expression predicts poor prognosis in gastric cancer
Q Xia, Y Zhou, H Yong, X Wang, W Zhao, G Ding… - … -Research and Practice, 2019 - Elsevier
Epiregulin (EREG) is a novel family member of EGF-like ligands and have elevated
expression in a variety of human cancers. EREG expression promotes tumor progression …
expression in a variety of human cancers. EREG expression promotes tumor progression …
[HTML][HTML] Epiregulin-blocking antibody inhibits epiregulin-dependent EGFR signaling
M Iijima, M Anai, T Kodama, Y Shibasaki - Biochemical and biophysical …, 2017 - Elsevier
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase involved in many
cellular functions including cell growth and migration. EGFR may be activated by EGF family …
cellular functions including cell growth and migration. EGFR may be activated by EGF family …
Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival
M Farooqui, LR Bohrer, NJ Brady, P Chuntova… - Molecular cancer, 2015 - Springer
Background The epidermal growth factor (EGF) family of ligands has been implicated in
promoting breast cancer initiation, growth and progression. The contributions of EGF family …
promoting breast cancer initiation, growth and progression. The contributions of EGF family …
Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter
X Qu, T Sandmann, H Frierson, L Fu, E Fuentes… - Oncogene, 2016 - nature.com
Key molecular drivers that underlie transformation of colonic epithelium into colorectal
adenocarcinoma (CRC) are well described. However, the mechanisms through which …
adenocarcinoma (CRC) are well described. However, the mechanisms through which …
ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma
S Götze, V Feldhaus, T Traska, M Wolter… - BMC cancer, 2009 - Springer
Background Cancer cells display widespread changes in DNA methylation that may lead to
genetic instability by global hypomethylation and aberrant silencing of tumor suppressor …
genetic instability by global hypomethylation and aberrant silencing of tumor suppressor …
High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor
G Auf, A Jabouille, M Delugin, S Guérit, R Pineau… - BMc cancer, 2013 - Springer
Background Epidermal growth factor (EGF) receptors contribute to the development of
malignant glioma. Here we considered the possible implication of the EGFR ligand …
malignant glioma. Here we considered the possible implication of the EGFR ligand …
Epiregulin expression by Ets-1 and ERK signaling pathway in Ki-ras-transformed cells
MC Cho, HS Choi, S Lee, BY Kim, M Jung… - Biochemical and …, 2008 - Elsevier
Epiregulin belongs to the epidermal growth factor family, binds to the epidermal growth
factor receptor, and its expression is upregulated in various cancer cells, but the regulatory …
factor receptor, and its expression is upregulated in various cancer cells, but the regulatory …
Promoter methylation of esophageal cancer-related gene 4 in gastric cancer tissue and its clinical significance.
YB Wang, CF Ba - Hepato-gastroenterology, 2012 - europepmc.org
Results The rate of ECRG4 promoter methylation was higher in gastric cancer tissues
(69.4%(34/49)) and peri-cancerous tissues (53.3%(16/30)) than in normal tissues …
(69.4%(34/49)) and peri-cancerous tissues (53.3%(16/30)) than in normal tissues …