Epiregulin belongs to the epidermal growth factor (EGF) family of polypeptides. Previous
studies have underscored the important role of the EGF family of ligands and receptors in …

Gastric cancer (GC) is one of the most common cancers and the second leading cause of
cancer-related mortality. Increasing discoveries have highlighted aberrant epigetic …

Although gastric cancer (GC) is highly prevalent in China and is a leading cause of cancer-
related death, major advances in early diagnostic and effective therapeutic strategies have …

Human breast cancer is a malignant form of tumor with a relatively high mortality rate.
Although esophageal cancer-related gene 4 (ECRG4) is thought to be a possible potent …

Aberrant DNA methylation is a potential mechanism underlying the development of
colorectal cancer (CRC). Thus, identification of prognostic DNA methylation markers and …

Background Esophageal squamous cell carcinoma (ESCC) is one of the most common
causes of cancer mortality in the gastrointestinal tract. Promoter hypermethylation of tumor …

Cancer: Is DNA methylation of tumour suppressor genes epigenetic? | eLife Skip to Content eLife
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Recent evidence has shown that the level of 5-hydroxymethylcytosine (5hmC) in
chromosomal DNA is aberrantly decreased in a variety of cancers, but whether this …

Background Many cancers show aberrant silencing of gene expression and overexpression
of histone methyltransferases. The histone methyltransferases (HKMT) EZH2 and EHMT2 …

Simple Summary Enhancer of zeste homolog 2 (EZH2) modifies the trimethylation of Lys-27
of histone 3, affecting downstream target genes' expression. It was reported that EZH2 is …