High-density genotyping: an overkill for QTL mapping? Lessons learned from a case study in maize and simulations

M Stange, HF Utz, TA Schrag, AE Melchinger… - Theoretical and applied …, 2013 - Springer
High-density genotyping is extensively exploited in genome-wide association mapping
studies and genomic selection in maize. By contrast, linkage mapping studies were until …

Multiple‐line cross quantitative trait locus mapping in European elite maize

J Steinhoff, W Liu, HP Maurer, T Würschum… - Crop …, 2011 - Wiley Online Library
Multiple‐line cross quantitative trait locus (QTL) mapping is considered a promising tool to
detect QTL with high power and substantial accuracy. The main goal of this study was to …

Quantitative trait locus mapping based on resampling in a vast maize testcross experiment and its relevance to quantitative genetics for complex traits

CC Schön, HF Utz, S Groh, B Truberg, S Openshaw… - Genetics, 2004 - academic.oup.com
From simulation studies it is known that the allocation of experimental resources has a
crucial effect on power of QTL detection as well as on accuracy and precision of QTL …

Combined linkage and linkage disequilibrium QTL mapping in multiple families of maize (Zea mays L.) line crosses highlights complementarities between models …

N Bardol, M Ventelon, B Mangin, S Jasson… - Theoretical and applied …, 2013 - Springer
Advancements in genotyping are rapidly decreasing marker costs and increasing marker
density. This opens new possibilities for mapping quantitative trait loci (QTL), in particular by …

Clusthaplo: a plug-in for MCQTL to enhance QTL detection using ancestral alleles in multi-cross design

D Leroux, A Rahmani, S Jasson, M Ventelon… - Theoretical and Applied …, 2014 - Springer
Key message We enhance power and accuracy of QTL mapping in multiple related families,
by clustering the founders of the families on their local genomic similarity. Abstract MCQTL is …

Comparison of biometrical approaches for QTL detection in multiple segregating families

W Liu, JC Reif, N Ranc, GD Porta… - Theoretical and Applied …, 2012 - Springer
Detection of QTL in multiple segregating families possesses many advantages over the
classical QTL mapping in biparental populations. It has thus become increasingly popular …

Joint-multiple family linkage analysis predicts within-family variation better than single-family analysis of the maize nested association mapping population

F Ogut, Y Bian, PJ Bradbury, JB Holland - Heredity, 2015 - nature.com
Quantitative trait locus (QTL) mapping has been used to dissect the genetic architecture of
complex traits and predict phenotypes for marker-assisted selection. Many QTL mapping …

Mapping QTL for agronomic traits in breeding populations

T Würschum - Theoretical and Applied Genetics, 2012 - Springer
Detection of quantitative trait loci (QTL) in breeding populations offers the advantage that
these QTL are of direct relevance for the improvement of crops via knowledge-based …

Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping

R Li, MA Lyons, H Wittenburg, B Paigen… - Genetics, 2005 - academic.oup.com
Rodent inbred line crosses are widely used to map genetic loci associated with complex
traits. This approach has proven to be powerful for detecting quantitative trait loci (QTL); …

Association mapping in an elite maize breeding population

W Liu, M Gowda, J Steinhoff, HP Maurer… - Theoretical and Applied …, 2011 - Springer
Association mapping (AM) is a powerful approach to dissect the genetic architecture of
quantitative traits. The main goal of our study was to empirically compare several statistical …