Background Pancreatic cancer (PC) remains the leading cause of cancer mortality, with
limited therapeutic targets, and alterations in endoplasmic reticulum (ER)-related …

Background Pancreatic ductal adenocarcinoma (PDAC) is a malignant pancreatic tumor
charactered by a rapid progression and high lethal rate. Hyperactivation of STAT3 signaling …

Leaf extracts of Pseuderanthemum palatiferum (Nees) Radlk were investigated for their
effects on human breast cancer MDA-MB-231 cell growth inhibition. Pseuderanthemum …

Physalis peruviana-derived physapruin A (PHA) is a potent compound that selectively
generates reactive oxygen species (ROS) and induces cancer cell death. Autophagy, a …

Regulated cell death (RCD) guarantees to preserve organismal homeostasis. Apoptosis and
autophagy are two major arms of RCD, while endoplasmic reticulum (ER) as a crucial …

Abstract The dismal 5-year survival (< 5%) for pancreatic cancer (PanCA) underscores the
need for developing effective therapeutic options. Recent studies from our laboratory have …

Chemotherapy, a major approach was used in carcinoma treatment, always involves the
development of drug resistance as well as side-effects that affect the quality of patients' lives …

Background Natural compounds extracted from plants have been reported to have antitumor
activity. A fungal metabolite from Phomopsis, identified as epoxycytochalasin H and isolated …

Apigenin, abundantly present in fruits and vegetables, is recognized as a flavonoid with anti-
inflammatory, antioxidant and anticancer properties. In this study, we first investigated the …

Endoplasmic reticulum (ER) stress is often closely linked to autophagy, hypoxia signaling,
mitochondrial biogenesis and reactive oxygen species (ROS) responses. Understanding the …