Human airways and glands express the anion channel cystic fibrosis transmembrane
conductance regulator, CFTR, and the epithelial Na+ channel, ENaC. Cystic fibrosis (CF) …

To model the airway glandular defect in cystic fibrosis (CF), the effect of anion secretion
blockers on submucosal gland mucus secretion was investigated. Porcine distal bronchi …

The cystic fibrosis transmembrane conductance regulator (CFTR) plays a significant role in
transepithelial salt absorption as well as secretion by a number of epithelial tissues …

We are testing the hypothesis that the malfunctioning of airway gland serous cells is a
component of cystic fibrosis (CF) airway disease. CF is caused by mutations that disrupt CF …

Cystic fibrosis (CF) airway disease arises from defective innate defenses, especially
defective mucus clearance of microorganisms. Airway submucosal glands secrete most …

Airway submucosal glands are important sites of cystic fibrosis transmembrane conductance
regulator (CFTR) chloride (Cl−) channel expression and fluid secretion in the airway …

It has been proposed that defective submucosal gland function in CF airways is a major
determinant of CF airway disease. We tested the hypothesis that submucosal gland function …

1 There is evidence that defective submucosal gland secretion contributes to the airway
pathology of cystic fibrosis (CF). Using a capacitance probe technique, we have compared …

Key points• Lung hydration and mucus clearance rates are set by a balance between CFTR‐
mediated Cl− secretion and ENaC‐led Na+ absorption. In CF airways, CFTR is diminished …

Cystic fibrosis is caused by mutations in CFTR, the cystic fibrosis transmembrane
conductance regulator gene. Disruption of CFTR‐mediated anion conductance results in …