Connexins (Cx), which constitute gap junction intercellular channels in vertebrates, have
been shown to suppress transformed cell growth and tumorigenesis, but the mechanism (s) …

In addition to providing a pathway for intercellular communication, the gap junction-forming
proteins, connexins, can serve a growth-suppressive function that is both connexin and cell …

Gap junctions, composed of proteins from the connexin family, allow for intercellular
communication between cells in tissues and are important in development, tissue/cellular …

Gap junction expression has been reported to control the growth of a variety of transformed
cells. We undertook parallel analysis of connexins Cx32 and Cx43 in glioma cells, which …

Communication between adjacent cells through gap junctions is believed to be involved in
the regulation of cell proliferation. This stems in part from the observation that transfection …

The Connexin (Cx) gene family acts as a tumor suppressor. However, it is unclear whether
the tumor-suppressing activity acquired by Cx gene transfection is mainly due to the …

Despite the tremendous amount of data over the last 40years, lack of gap junctional
intercellular communication (GJIC) or altered expression of gap junction proteins is still a …

Simple Summary Different connexins play diverse roles in cancers, either tumor-
suppressing or tumor-promoting. In lung cancer, Cx43 serves as a tumor suppressor at the …

The coordination of complex tumor processes requires cells to rapidly modify their
phenotype and is achieved by direct cell-cell communication through gap junction channels …

Direct communication between cells via gap junctions is thought to be an important
component of homeostasis and coordinated cellular responses to external signals. We …