[HTML][HTML] AMPK activation protects astrocytes from hypoxia-induced cell death

L Barialai, MI Strecker, AL Luger… - International …, 2020 - spandidos-publications.com
Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a major cellular
energy sensor that is activated by an increase in the AMP/adenosine triphosphate (ATP) …

The role of AMPK pathway in neuroprotection

L Xu, JD Ash - Retinal Degenerative Diseases: Mechanisms and …, 2016 - Springer
Adenosine monophosphate-activated kinase (AMPK) is a highly conserved protein kinase
found in all eukaryotic genomes. It exists as heterotrimeric protein consisting of α, β, and γ …

Role of 5′-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons

P Weisová, D Dávila, LP Tuffy, MW Ward… - Antioxidants & redox …, 2011 - liebertpub.com
Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of
cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and …

AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons

MR Spasić, P Callaerts, KK Norga - The Neuroscientist, 2009 - journals.sagepub.com
AMP-activated protein kinase (AMPK) constitutes a molecular hub for cellular metabolic
control, common to all eukaryotic cells. Numerous reports have established how AMPK …

Mechanistic insights on impact of Adenosine monophosphate-activated protein kinase (AMPK) mediated signalling pathways on cerebral ischemic injury

P Kalra, H Khan, TG Singh, AK Grewal - Neuroscience Research, 2023 - Elsevier
Cerebral ischemia is the primary cause of morbidity and mortality worldwide due to the
perturbations in the blood supply to the brain. The brain triggers a cascade of complex …

mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival

C Garza-Lombó, A Schroder, EM Reyes-Reyes… - Current opinion in …, 2018 - Elsevier
The mechanistic (or mammalian) target of rapamycin (mTOR) and the adenosine
monophosphate-activated protein kinase (AMPK) regulate cell survival and metabolism in …

AMP‐activated protein kinase is involved in induction of protective autophagy in astrocytes exposed to oxygen‐glucose deprivation

B Gabryel, A Kost, D Kasprowska, S Liber… - Cell biology …, 2014 - Wiley Online Library
AMP‐activated kinase (AMPK) acts as the intracellular ATP depletion sensor, which detects
and limits increases in the AMP/ATP ratio. AMPK may be significantly activated under stress …

Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin …

CH Lin, CJB Nicol, YC Cheng, C Yen, YS Wang… - Brain Research, 2020 - Elsevier
Ischemic stroke arising from the sudden blockage of arteries in the brain, is a common and
serious brain damaging problem worldwide, often leading to disability or death. The oxygen …

Expanding roles for AMP‐activated protein kinase in neuronal survival and autophagy

J Poels, MR Spasić, P Callaerts, KK Norga - Bioessays, 2009 - Wiley Online Library
AMP‐activated protein kinase (AMPK) is an evolutionarily conserved cellular switch that
activates catabolic pathways and turns off anabolic processes. In this way, AMPK activation …

Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose …

R Ciccarelli, I D'Alimonte, P Ballerini, M D'Auro… - Molecular …, 2007 - ASPET
Astrocyte death may occur in neurodegenerative disorders and complicates the outcome of
brain ischemia, a condition associated with high extracellular levels of adenosine and …