The main objective of this publication is to make the reader aware of the complexity and
steps that are necessary to make a Food and Drug Administration (FDA)-approved …

The soft tissue reconstruction of significant avulsed and/or surgically created tissue defects
requires the ability to manufacture substantial soft tissue constructs for repair of the resulting …

Tissue-engineered oral mucosa, in the form of epithelial cell sheets or full-thickness oral
mucosa equivalents, is a potential solution for many patients with congenital defects or with …

Tissue-engineered oral mucosal equivalents have been developed for clinical applications
and also for in vitro studies of biocompatibility, mucosal irritation, disease, and other basic …

The artificial generation of tissues, organs, or even more complex living organisms was
throughout the history of mankind a matter of myth and dream. During the last decades this …

Within the past decade, a new field of “tissue engineering” or “regenerative medicine” has
emerged that offers a new and exciting alternative for maxillofacial reconstruction. It offers …

The recent advances in the field of cell-based therapeutics open promising perspectives for
oral tissue regeneration. The development of large animal models, which overcome the …

Immunologically inert allogeneic acellular dermal scaffolds provide a matrix with molecular
architecture close to native tissues, which synthetic scaffolds cannot. Not all nature‐derived …

To cite this article: Liu J, Bian Z, Kuijpers‐Jagtman AM, Von den Hoff JW: Skin and oral
mucosa equivalents: construction and performance Orthod Craniofac Res 2010; 13: 11–20 …

Engineering of various oral tissues is a challenging issue in contemporary maxillofacial
reconstructive research. In contrast to the classic biomaterial approach, tissue engineering is …