Four separate initiation sites for neural tube (NT) fusion have been demonstrated recently in
mice and other experimental animals. We evaluated the question of whether the mult‐site …

Although neural tube defects are a common congenital anomaly, their etiology is not known.
Human studies have emphasized the pathology and epidemiology of the defects and …

A variety of human birth defects originate in failure of closure of the embryonic neural tube.
The genetic cause of the most common nonsyndromic defects, spina bifida (SB) or …

The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth
defects of the central nervous system that originate during embryonic development when the …

The worldwide incidence of neural tube defects (NTDs) ranges from 1.0 to 10.0 per 1,000
births with almost equal frequencies between two major categories: anencephaly and spina …

While neural tube defects (NTD) overall have a female sex bias, this does not apply to all
sites along the neuraxis. The findings regarding sex and NTD in a series of midtrimester …

Neural tube defects (NTDs)—malformations secondary to abnormal neural tube closure
between the third and fourth weeks of gestational age—have a complex and imperfectly …

Neural tube defects (NTD) in humans have been considered to have a multifactorial
aetiology, however the participating genes have not been identified. The curly–tail (ct) …

Hope Northrup, MD, and Kelly A. Volcik~ eural tube defects (NTDs) are the most common
severely disabling birth defects in the United States, with a frequency of approximately 1 of …