Hope Northrup, MD, and Kelly A. Volcik~ eural tube defects (NTDs) are the most common
severely disabling birth defects in the United States, with a frequency of approximately 1 of …

We examined clinical, genetic, and epidemiologic factors among 512 probands with
nonsyndromal neural tube defects (NTDs). Data were analyzed after grouping the probands …

Mouse embryos homozygous for the mutation loop-tail (Lp) develop lethal defects in which
the neural tube remains open from the hindbrain to the caudal extremity, a condition that …

Objective. Anterior neural tube closure in humans is thought to occur via a continuous
process, culminating in the closure of the anterior neuropore. Recent studies have …

Spina bifida is among the phenotypes of the larger condition known as neural tube defects
(NTDs). It is the most common central nervous system malformation compatible with life and …

We describe a new mouse mutation, designated open brain (opb), which results in severe
defects in the developing neural tube. Homozygous opb embryos exhibited an exen …

The developmental process of neurulation involves a series of coordinated morphological
events, which result in conversion of the flat neural plate into the neural tube, the primordium …

The epidemiological investigation of the common open neural tube defects (NTDs),
anencephaly, and spina bifida, has a long history. The most significant finding from these …

Neural tube defects (NTD) remain a major cause of morbidity in spite of the reduction in
liveborn incidence with periconceptional folic acid. However, the etiology remains unknown …

We previously reported that among neural tube defects (NTDs) with no known causes the
ones that occur alone (singles) have different epidemiologic characteristics from those that …