Isolated neural tube defects (NTDs) appear to have different risk factors compared to
nonisolated NTDs. To extend those observations, we explored routinely collected child and …

The authors review current views on of the embryogenesis of the neural tube defects (NTDs)
myelomeningocele and anencephaly. In this context, the following four approaches to the …

Delayed closure of the posterior neuropore (PNP) occurs to a variable extent in homozygous
mutant curly tail (ct) mouse embryos, and results in the development of spinal neural tube …

Susceptibility to neural tube defects (NTDs), such as anencephaly and spina bifida is
influenced by genetic and environmental factors including maternal nutrition. Maternal …

Biochemical and developmental pathways, mouse models, and positional evidence have
provided numerous candidate genes for the study of human neural tube defects. In a survey …

Circletail is one of only two mouse mutants that exhibit the most severe form of neural tube
defect (NTD), termed craniorachischisis. In this disorder, almost the entire brain and spinal …

Periconceptional folic acid (FA) supplementation significantly reduces the prevalence of
neural tube defects (NTDs). Unfortunately, some NTDs are FA resistant, and as such, NTDs …

Neural tube defects (NTDs) are common, severe congenital malformations whose causation
involves multiple genes and environmental factors. Although more than 200 genes are …

Human structural congenital malformations are the leading cause of infant mortality in the
United States. Estimates from the United States Center for Disease Control and Prevention …