Therapeutic intervention in cancer by isoliquiritigenin from licorice: a natural antioxidant and redox regulator
Z Zhang, KKL Yung, JKS Ko - Antioxidants, 2022 - mdpi.com
Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration
and cancer, which are closely associated with intracellular signal transducers such as …
and cancer, which are closely associated with intracellular signal transducers such as …
Perspectives on the Role of Isoliquiritigenin in Cancer
KL Wang, YC Yu, SM Hsia - Cancers, 2021 - mdpi.com
Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …
Dietary compound isoliquiritigenin, an antioxidant from licorice, suppresses triple-negative breast tumor growth via apoptotic death program activation in cell and …
Patients with triple-negative breast cancer have few therapeutic strategy options. In this
study, we investigated the effect of isoliquiritigenin (ISL) on the proliferation of triple-negative …
study, we investigated the effect of isoliquiritigenin (ISL) on the proliferation of triple-negative …
Isoliquiritigenin inhibits proliferation and induces apoptosis via alleviating hypoxia and reducing glycolysis in mouse melanoma B16F10 cells
Y Wang, J Ma, X Yan, X Chen, L Si… - Recent patents on …, 2016 - ingentaconnect.com
Background: Isoliquiritigenin (ISL) is a licorice chalcone. According to CN104758274,
CN101658513 and US009089546, it is claimed that ISL has anti-inflammatory, anti …
CN101658513 and US009089546, it is claimed that ISL has anti-inflammatory, anti …
A review: the pharmacology of isoliquiritigenin
Isoliquiritigenin (ISL) is one of the bioactive ingredients isolated from the roots of plants
belonging to licorice, including Glycyrrhiza uralensis, Mongolian glycyrrhiza, Glycyrrhiza …
belonging to licorice, including Glycyrrhiza uralensis, Mongolian glycyrrhiza, Glycyrrhiza …
ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro
L Song, Y Luo, S Li, M Hong, Q Wang… - Drug Design …, 2020 - Taylor & Francis
Aims Isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, has previously been
reported to have anti-tumor effects in vivo and in vitro. However, the mechanisms whereby …
reported to have anti-tumor effects in vivo and in vitro. However, the mechanisms whereby …
Isoliquiritigenin inhibits pancreatic cancer progression through blockade of p38 MAPK-regulated autophagy
Z Zhang, W Chen, S Zhang, J Bai, B Liu, KKL Yung… - Phytomedicine, 2022 - Elsevier
Background Pancreatic cancer has been characterized by poor prognosis, early metastasis
and dissatisfactory treatment outcome. The high basal level of autophagy in tumor cells …
and dissatisfactory treatment outcome. The high basal level of autophagy in tumor cells …
Isoliquiritigenin induces autophagy and inhibits ovarian cancer cell growth
HY Chen, TC Huang, TM Shieh, CH Wu, LC Lin… - International journal of …, 2017 - mdpi.com
Ovarian cancer is one of the commonest gynecologic malignancies, which has a poor
prognosis for patients at the advanced stage. Isoliquiritigenin (ISL), an active flavonoid …
prognosis for patients at the advanced stage. Isoliquiritigenin (ISL), an active flavonoid …
Mechanisms underlying isoliquiritigenin‐induced apoptosis and cell cycle arrest via ROS‐mediated MAPK/STAT3/NF‐κB pathways in human hepatocellular …
JR Wang, YH Luo, XJ Piao, Y Zhang… - Drug Development …, 2019 - Wiley Online Library
Isoliquiritigenin (ISL), a natural flavonoid isolated from plant licorice, has various
pharmacological properties, including anticancer, anti‐inflammatory, and antiviral effects …
pharmacological properties, including anticancer, anti‐inflammatory, and antiviral effects …
[HTML][HTML] Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway
XR Zhang, SY Wang, W Sun… - Molecular medicine …, 2018 - spandidos-publications.com
Isoliquiritigenin (ISL) is a flavonoid extracted from licorice root, which is known to serve
important antitumor roles in numerous types of cancers; however, its effect on gastric cancer …
important antitumor roles in numerous types of cancers; however, its effect on gastric cancer …