[HTML][HTML] Multiple biological effects of an iridoid glucoside, catalpol, and its underlying molecular mechanisms

SK Bhattamisra, KH Yap, V Rao, H Choudhury - Biomolecules, 2019 - mdpi.com
Catalpol, an iridoid glucoside, is widely distributed in many plant families and is primarily
obtained from the root of Rehmannia glutinosa Libosch. Rehmannia glutinosa is a plant very …

[HTML][HTML] Licorice (Glycyrrhiza glabra L.)-derived phytochemicals target multiple signaling pathways to confer oncopreventive and oncotherapeutic effects

HS Tuli, VK Garg, JK Mehta, G Kaur… - OncoTargets and …, 2022 - ncbi.nlm.nih.gov
Cancer is a highly lethal disease, and its incidence has rapidly increased worldwide over
the past few decades. Although chemotherapeutics and surgery are widely used in clinical …

Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia‐telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous …

SM Hsia, CC Yu, YH Shih, M Yuanchien Chen… - Head & …, 2016 - Wiley Online Library
Background Isoliquiritigenin (ISL), a natural compound extracted from licorice, has
chemopreventive and antitumor activities. The purpose of this study was to investigate the …

[HTML][HTML] Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway

C Zhang, L Huang, J Xiong, L Xie, S Ying, Y Jia, Y Yao… - PloS one, 2021 - journals.plos.org
Background/aims Isoalantolactone (IATL) is one of multiple isomeric sesquiterpene lactones
and is isolated from inula helenium. IATL has multiple functions such as antibacterial …

[HTML][HTML] Phytochemical and pharmacological role of liquiritigenin and isoliquiritigenin from radix glycyrrhizae in human health and disease models

M Ramalingam, H Kim, Y Lee, YI Lee - Frontiers in aging …, 2018 - frontiersin.org
The increasing lifespan in developed countries results in age-associated chronic diseases.
Biological aging is a complex process associated with accumulated cellular damage by …

Liquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo

Y Ji, W Hu, Y Jin, H Yu, J Fang - Bioengineered, 2021 - Taylor & Francis
Operative treatment on oral cancer greatly damages the chewing and language function of
the patient, we aim to find better solution with fewer side effects. The anti-tumor effects of …

Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells

X Yuan, B Zhang, N Chen, XY Chen… - Journal of Asian …, 2012 - Taylor & Francis
This study focuses on the relationship between the apoptosis induced by isoliquiritigenin
(ISL) and the production of reactive oxygen species (ROS). Cell viability was evaluated …

[HTML][HTML] Icariside II: anticancer potential and molecular targets in solid cancers

F Xu, Q Wu, L Li, J Gong, R Huo, W Cui - Frontiers in Pharmacology, 2021 - frontiersin.org
Icariside II, an active flavonoid, is extracted from the traditional Chinese medicinal herb
Epimedii. It possesses multiple biological and pharmacological properties, including anti …

[HTML][HTML] Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells

A Kim, JY Ma - Frontiers in Pharmacology, 2018 - frontiersin.org
Several components isolated from Glycyrrhizae radix rhizome (GR), including glycyrrhizin,
liquiritin, and liquiritigenin, have been shown to induce cancer cell death and inhibit cancer …

Identification of phenolics in litchi and evaluation of anticancer cell proliferation activity and intracellular antioxidant activity

L Wen, L You, X Yang, J Yang, F Chen, Y Jiang… - Free Radical Biology …, 2015 - Elsevier
Litchi leaf is a good resource for phenolics, which are good candidates for medicines. In this
work, three phenolics were isolated from litchi leaf by column chromatography. Their …