Imaging of the interaction of cancer cells and the lymphatic system

HST Cao, M McElroy, S Kaushal, RM Hoffman… - Advanced drug delivery …, 2011 - Elsevier
A thorough understanding of the lymphatic system and its interaction with cancer cells is
crucial to our ability to fight cancer metastasis. Efforts to study the lymphatic system had …

Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo

M McElroy, K Hayashi, B Garmy-Susini… - Journal of Surgical …, 2009 - Elsevier
BACKGROUND: The lymphatic system is a major route for cancer cell dissemination, and a
potential target for antitumor therapy. Despite ongoing interest in this area of research, the …

Fluorescent Tracers for In Vivo Imaging of Lymphatic Targets

PS Russell, R Velivolu… - Frontiers in …, 2022 - frontiersin.org
The lymphatic system continues to gain importance in a range of conditions, and therefore,
imaging of lymphatic vessels is becoming more widespread for research, diagnosis, and …

Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels

K Hayashi, P Jiang, K Yamauchi, N Yamamoto… - Cancer research, 2007 - AACR
In the present report, we show real-time imaging of cancer cell trafficking in lymphatic
vessels. Cancer cells labeled with both green fluorescent protein (GFP) in the nucleus and …

[HTML][HTML] Lymphatic drug delivery: therapy, imaging and nanotechnology

MS Cohen, ML Forrest - Advanced drug delivery reviews, 2011 - ncbi.nlm.nih.gov
The lymphatic system represents a relatively untapped biological highway to deliver
targeted drug molecules, nanoparticle drug-conjugates, imaging agents, vaccines and gene …

Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis

ST Proulx, P Luciani, A Christiansen, S Karaman… - Biomaterials, 2013 - Elsevier
Tumor lymphangiogenesis promotes metastatic cancer spread to lymph nodes and beyond.
However, the potential remodeling and functionality of tumor-draining lymphatic vessels has …

Advances in lymphatic imaging and drug delivery

SK Nune, P Gunda, BK Majeti, PK Thallapally… - Advanced drug delivery …, 2011 - Elsevier
Cancer remains the second leading cause of death after heart disease in the US. While
metastasized cancers such as breast, prostate, and colon are incurable, before their distant …

Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles

D Olmeda, D Cerezo-Wallis, E Castellano-Sanz… - Advanced Drug Delivery …, 2021 - Elsevier
Imaging of the lymphatic vasculature has gained great attention in various fields, not only
because lymphatic vessels act as a key draining system in the body, but also for their …

Functional lymphatic imaging in tumor-bearing mice

S Kwon, EM Sevick-Muraca - Journal of immunological methods, 2010 - Elsevier
The lymphatic system provides a route for dissemination of metastatic cancer cells. Yet to
date transient changes in lymphatic drainage pathways and function as a result of tumor …

Lymphatic delivery and targeting of drugs, vaccines, and imaging agents

S Han, N Trevaskis, P Gershkovich… - Frontiers in …, 2022 - frontiersin.org
The lymphatic system plays a key role in the (patho) physiology of a number of diseases,
including autoimmune/inflammatory disorders, cancer, infections, and metabolic syndrome …