Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19-and SDH2-Mediated Cellular Metabolism

S Wang, J Qiao, C Jiang, D Pan, S Yu, J Chen, S Liu… - Antioxidants, 2023 - mdpi.com
Ginsenosides, active substances in Panax ginseng CA Meyer (ginseng), extend lifespan in
multiple species, ameliorate age-associated damage, and limit functional decline in multiple …

Ginsenoside Rb1 retards aging process by regulating cell cycle, apoptotic pathway and metabolism of aging mice

S Yu, H Xia, Y Guo, X Qian, X Zou, H Yang… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Ginsenoside Rb1 (GRb1), an active ingredient of
traditional Chinese medicine Panax ginseng CA Meyer, has displayed various activities …

[HTML][HTML] Stereoisomer-specific ginsenoside 20 (S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling

KE Yang, HJ Jang, IH Hwang, EM Hong… - Journal of ginseng …, 2020 - Elsevier
Background The replicative senescence of human dermal fibroblasts (HDFs) is
accompanied by growth arrest. In our previous study, the treatment of senescent HDFs with …

Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans

H Wang, S Zhang, L Zhai, L Sun, D Zhao, Z Wang… - Food & Function, 2021 - pubs.rsc.org
Nutrition intervention has become a potential strategy to improve healthspan and prolong
lifespan. Ginseng has been used for thousands of years and developed as a functional food …

Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling Pathway

X Yu, H Li, D Lin, W Guo, Z Xu, L Wang… - International journal of …, 2021 - mdpi.com
Panax ginseng is a valuable traditional Chinese medicine in Northeast China. Ginsenoside,
the active component of ginseng, has not been investigated much for its effects on aging and …

[HTML][HTML] Proteomic analyses reveal that ginsenoside Rg3 (S) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin

IS Jang, E Jo, SJ Park, SJ Baek, IH Hwang… - Journal of Ginseng …, 2020 - Elsevier
Background The cellular senescence of primary cultured cells is an irreversible process
characterized by growth arrest. Restoration of senescence by ginsenosides has not been …

Black ginseng ameliorates cellular senescence via p53-p21/p16 pathway in aged mice

SJ Lee, DY Lee, JF O'Connell, JM Egan, Y Kim - Biology, 2022 - mdpi.com
Simple Summary The goal of this study was to examine if BG impacts the aging process,
specifically cellular senescence, using in vitro and aged mouse models. Primary mouse …

Red Ginseng Attenuates the Hepatic Cellular Senescence in Aged Mice

DY Lee, J Arndt, JF O'Connell, JM Egan, Y Kim - Biology, 2024 - mdpi.com
Simple Summary The aim of this study was to explore the potential impact of red ginseng
(RG) on age-associated cellular senescence through in vitro, ex vivo, and 19-month-old …

The anti-aging mechanism of ginsenosides with medicine and food homology

T Tian, CN Ko, W Luo, D Li, C Yang - Food & Function, 2023 - pubs.rsc.org
With the acceleration of global aging and the rise in living standards, the achievement of
healthy aging is becoming an imperative issue globally. Ginseng, a medicinal plant that has …

Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor

R Qi, R Jiang, H Xiao, Z Wang, S He, L Wang, Y Wang - Life Sciences, 2020 - Elsevier
Aims Rg1 is the most active component of traditional Chinese medicine ginseng, having anti-
aging and anti-oxidative stress features in multiple organs. Cellular senescence of …