Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology

S Grässel, F Zaucke, H Madry - Journal of clinical medicine, 2021 - mdpi.com
Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …

NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation

F Zhang, Y Wang, Y Zhao, M Wang, B Zhou, X Ge - Elife, 2023 - elifesciences.org
The origin and differentiation mechanism of articular chondrocytes remain poorly
understood. Broadly, the difference in developmental mechanisms of articular and growth …

Osteoarthritis: a narrative review of molecular approaches to disease management

LA Salman, G Ahmed, SG Dakin, B Kendrick… - Arthritis Research & …, 2023 - Springer
Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …

Cartilage biology, pathology, and repair

D Umlauf, S Frank, T Pap, J Bertrand - Cellular and molecular life sciences, 2010 - Springer
Osteoarthritis is one of the most common forms of musculoskeletal disease and the most
prominent type of arthritis encountered in all countries. Although great efforts have been …

Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets

HI Roach, T Aigner, S Soder, J Haag… - Current Drug …, 2007 - ingentaconnect.com
Osteoarthritis, a degenerative joint disease, is the most disabling condition of the Western
world. It affects first and foremost the articular cartilages and leads to a molecular and …

[HTML][HTML] Current concepts in the pathogenesis of osteoarthritis

S Krasnokutsky, M Attur, G Palmer, J Samuels… - Osteoarthritis and …, 2008 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

W Hu, Y Chen, C Dou, S Dong - Annals of the Rheumatic Diseases, 2021 - ard.bmj.com
Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

Mechanism of cartilage destruction in osteoarthritis.

N Ishiguro, T Kojima, AR Poole - Nagoya journal of medical science, 2002 - europepmc.org
Osteoarthritis (OA) is one of the most common diseases among the elderly. For many years,
OA was considered a normal result of the aging process with few treatment options …

Regulatory mechanisms of chondrogenesis and implications for understanding articular cartilage homeostasis

C Hidaka, MB Goldring - Current Rheumatology Reviews, 2008 - ingentaconnect.com
Studies of chondrogenesis and embryonic limb development offer a wealth of knowledge
regarding signals that regulate the behavior of chondrocytes. Many such chondrogenic …

[HTML][HTML] Osteoarthritis year in review 2013: biology

RF Loeser - Osteoarthritis and Cartilage, 2013 - Elsevier
The purpose of this review was to present highlights from the published literature on the
topic of the biology of osteoarthritis (OA). A PubMed search was conducted in order to locate …