Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …

Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

The enhanced permeability and retention (EPR) of nanoparticles in tumors has long stood
as one of the fundamental principles of cancer drug delivery, holding the promise of safe …

Enhanced permeability and retention (EPR) effect is a popular strategy for targeting
nanosize anticancer drugs to tumor tissues. In this review we discuss how EPR effect …

Poor penetration of anticancer drags into solid tumors significantly limits their efficacy. This
phenomenon has long been observed for small-molecule chemotherapeutics, and it can be …

Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor
interstitial space, whereas the suppressed lymphatic filtration allows them to stay there. This …

Effective cancer therapy remains one of the most challenging tasks to the scientific
community, with little advancement on overall cancer survival landscape during the last two …

The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …

Introduction: A major problem with conventional antitumor therapeutics is nonselective
delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor …

Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …