Natural products (NPs), or specialized metabolites, are important for medicine and
agriculture alike, and for the fitness of the organisms that produce them. NP genome-mining …

Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …

Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …

Highlights•A lexicon for biosynthetic gene clusters and the small molecules they
encode.•Omic approaches advance natural product discovery.•Knowledge gaps in the …

Natural products are structurally highly diverse and exhibit a wide array of biological
activities. As a result, they serve as an important source of new drug leads. Traditionally …

Microbes host a huge variety of biosynthetic gene clusters that produce an immeasurable
array of secondary metabolites with many different biological activities such as antimicrobial …

Natural products (NPs) are a major source of compounds for medical, agricultural, and
biotechnological industries. Many of these compounds are of microbial origin, and, in …

The pairing of analytical chemistry with genomic techniques represents a new wave in
natural product chemistry. With an increase in the availability of sequencing and assembly of …

New bioinformatic tools are needed to analyze the growing volume of DNA sequence data.
This is especially true in the case of secondary metabolite biosynthesis, where the highly …

Microbial genome mining is a promising technology that is revitalizing natural product
discovery. It is now well documented that many bacteria with large genomes, particularly …