The biology of infertility: research advances and clinical challenges
Reproduction is required for the survival of all mammalian species, and thousands of
essential'sex'genes are conserved through evolution. Basic research helps to define these …
essential'sex'genes are conserved through evolution. Basic research helps to define these …
[HTML][HTML] Genetic dissection of mammalian fertility pathways
The world's population is increasing at an alarming rate and is projected to reach nine billion
by 2050. Despite this, 15% of couples world-wide remain childless because of infertility. Few …
by 2050. Despite this, 15% of couples world-wide remain childless because of infertility. Few …
Understanding the genetics of human infertility
Q Sang, PF Ray, L Wang - Science, 2023 - science.org
Reproduction involves a wide range of biological processes, including organ formation and
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …
Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice
SY Jiao, YH Yang, SR Chen - Human reproduction update, 2021 - academic.oup.com
BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
[HTML][HTML] The genetics of infertility: current status of the field
M Zorrilla, AN Yatsenko - Current genetic medicine reports, 2013 - Springer
Infertility is a relatively common health condition, affecting nearly 7% of all couples.
Clinically, it is a highly heterogeneous pathology with a complex etiology that includes …
Clinically, it is a highly heterogeneous pathology with a complex etiology that includes …
Understanding new genetics of male infertility
Purpose: Greater than 10% of couples are unable to achieve pregnancy. In at least 30% to
50% of these infertility cases a male factor abnormality is involved. Genetic defects are …
50% of these infertility cases a male factor abnormality is involved. Genetic defects are …
Genetic causes of human reproductive disease
JC Achermann, G Ozisik, JJ Meeks… - The Journal of Clinical …, 2002 - academic.oup.com
Disorders of reproduction represent a significant social, medical, and economic burden for
individuals and society. Approximately 1 in 10 couples in the United States are infertile, and …
individuals and society. Approximately 1 in 10 couples in the United States are infertile, and …
[HTML][HTML] Genetics of male infertility: from research to clinic
Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …
representation and in at least 15% of cases, this condition is related to known genetic …
The state of the union: the cell biology of fertilization
JP Evans, HM Florman - Nature medicine, 2002 - nature.com
Look at songs, hidden in eggs. Carl Sandburg in Prairie Fertilization is the process by which
sperm and egg unite. An expanded understanding of the mechanisms that underlie these …
sperm and egg unite. An expanded understanding of the mechanisms that underlie these …
[HTML][HTML] Deconstructing mammalian reproduction: using knockouts to define fertility pathways
A Roy, MM Matzuk - Reproduction, 2006 - rep.bioscientifica.com
Reproduction is the sine qua non for the propagation of species and continuation of life. It is
a complex biological process that is regulated by multiple factors during the reproductive life …
a complex biological process that is regulated by multiple factors during the reproductive life …