Integrins form a large family of cell surface receptors that mediate cell-extracellular matrix
interactions. In the third minireview, entitled “Integrins, Redundant or Important Players in …

In striated muscle, the cytoskeletal protein dystrophin, the protein product of the Duchenne
muscular dystrophy gene, is associated with a number of sarcolemmal glycoproteins to form …

Sarcoglycan is a multimeric, integral membrane glycoprotein complex that associates with
dystrophin. Mutations in individual sarcoglycan subunits have been identified in inherited …

The dystrophin-glycoprotein complex (DGC) 1 is a multimeric transmembrane protein
complex first isolated from skeletal muscle membranes (1). The central protein of the DGC is …

In humans, mutations in the genes encoding components of the dystrophin–glycoprotein
complex cause muscular dystrophy. Specifically, primary mutations in the genes encoding α …

Dystroglycan provides a crucial linkage between the cytoskeleton and the basement
membrane for skeletal muscle cells. Disruption of this linkage leads to various forms of …

Migration of myogenic cells from the somites and their subsequent fusion to myotubes are
key steps during skeletal muscle development. Continuous interaction of the cells with the …

Disruption of the sarcoglycan complex leads to muscle membrane instability and muscular
dystrophy in humans and mice. Through the dystrophin glycoprotein complex, sarcoglycan …

Dystroglycan, a central component of the skeletal muscle dystrophin glycoprotein complex
(DGC), plays a key role in maintaining normal muscle function. Initially encoded as a single …

Skeletal muscle basal lamina is linked to the sarcolemma through transmembrane
receptors, including integrins and dystroglycan. The function of dystroglycan relies critically …