Toxicogenomics–what added value do these approaches provide for carcinogen risk assessment?
S Schmitz-Spanke - Environmental research, 2019 - Elsevier
It is still a major challenge to protect humans at workplaces and in the environment. To cope
with this task, it is a prerequisite to obtain detailed information on the extent of chemical …
with this task, it is a prerequisite to obtain detailed information on the extent of chemical …
Progress in toxicogenomics to protect human health
Toxicogenomics measures molecular features, such as transcripts, proteins, metabolites and
epigenomic modifications, to understand and predict the toxicological effects of …
epigenomic modifications, to understand and predict the toxicological effects of …
Current and future use of genomics data in toxicology: opportunities and challenges for regulatory applications
AK Goetz, BP Singh, M Battalora, JM Breier… - Regulatory Toxicology …, 2011 - Elsevier
Toxicogenomics is the application of toxicology, genetics, molecular biology and
environmental health to describe the response of organisms to environmental stimuli. The …
environmental health to describe the response of organisms to environmental stimuli. The …
Transcriptomics in toxicogenomics, part I: experimental design, technologies, publicly available data, and regulatory aspects
The starting point of successful hazard assessment is the generation of unbiased and
trustworthy data. Conventional toxicity testing deals with extensive observations of …
trustworthy data. Conventional toxicity testing deals with extensive observations of …
The state-of-the art of environmental toxicogenomics: Challenges and perspectives of “omics” approaches directed to toxicant mixtures
The last decade witnessed extraordinary advances in “omics” methods, particularly
transcriptomics, proteomics and metabolomics, enabling toxicologists to integrate …
transcriptomics, proteomics and metabolomics, enabling toxicologists to integrate …
How can toxicogenomics inform risk assessment?
A Oberemm, L Onyon, U Gundert-Remy - Toxicology and applied …, 2005 - Elsevier
Technologies that generate information about the genome are being used to explore
changes in gene expression and related proteins following exposure to chemicals …
changes in gene expression and related proteins following exposure to chemicals …
Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches
While scientific knowledge of the potential health significance of chemical exposures has
grown, experimental methods for predicting the carcinogenicity of environmental agents …
grown, experimental methods for predicting the carcinogenicity of environmental agents …
The use of omics-based approaches in regulatory toxicology: an alternative approach to assess the no observed transcriptional effect level
The evaluation of chemical hazard is based on the identification of the quality and the
quantity of adverse effects as a consequence of exposure. The adverse effects that do not …
quantity of adverse effects as a consequence of exposure. The adverse effects that do not …
Toxicogenomics: regulatory perspective on current position
JM Battershill - Human & experimental toxicology, 2005 - journals.sagepub.com
Published studies on the utility of toxicogenomic approaches (transcriptomics, proteomics
and metabonomics) in screening for toxicological mechanisms and evaluation of dose …
and metabonomics) in screening for toxicological mechanisms and evaluation of dose …
Perspectives on the use of toxicogenomics to assess environmental risk
J Portugal, S Mansilla, B Piña - Frontiers in bioscience (Landmark …, 2022 - digital.csic.es
Environmental toxicogenomics aims to collect, analyze and interpret data on changes in
gene expression and protein activity resulting from exposure to toxic substances using high …
gene expression and protein activity resulting from exposure to toxic substances using high …