Diverse expression patterns of the EMT suppressor grainyhead‐like 2 (GRHL 2) in normal and tumour tissues

S Riethdorf, S Frey, S Santjer… - … Journal of Cancer, 2016 - Wiley Online Library
The transcription factor grainyhead‐like 2 (GRHL2) plays a crucial role in various
developmental processes. Although GRHL2 recently has attracted considerable interest in …

Silencing of GRHL2 induces epithelial‑to‑mesenchymal transition in lung cancer cell lines with different effects on proliferation and clonogenic growth

N Kawabe, K Matsuoka, K Komeda… - Oncology …, 2023 - spandidos-publications.com
Abstract Grainyhead‑like 2 (GRHL2) is a transcription factor that suppresses epithelial‑to‑
mesenchymal transition (EMT). It has been previously shown that GRHL2 can confer both …

Suppression of the epithelial–mesenchymal transition by Grainyhead-like-2

B Cieply, P Riley IV, PM Pifer, J Widmeyer, JB Addison… - Cancer research, 2012 - AACR
Grainyhead genes are involved in wound healing and developmental neural tube closure. In
light of the high degree of similarity between the epithelial–mesenchymal transitions (EMT) …

[HTML][HTML] Expression of transcription factor grainyhead-like 2 is diminished in cervical cancer

LA Torres-Reyes, L Alvarado-Ruiz… - … Journal of Clinical …, 2014 - ncbi.nlm.nih.gov
The transcription factor grainyhead-like 2 (GRHL2) is evolutionarily conserved in many
different species, and is involved in morphogenesis, epithelial differentiation, and the control …

[HTML][HTML] Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer

S Werner, S Frey, S Riethdorf, C Schulze… - Journal of biological …, 2013 - ASBMB
Using a retrovirus-mediated cDNA expression cloning approach, we identified the
grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of …

[HTML][HTML] Grhl2 determines the epithelial phenotype of breast cancers and promotes tumor progression

X Xiang, ZB Deng, X Zhuang, S Ju, J Mu, H Jiang… - PloS one, 2012 - journals.plos.org
Until now the essential transcription factor that determines the epithelial phenotype of breast
cancer has not been identified and its role in epithelial-to-mesenchymal transition (EMT) and …

Grainyhead-like protein 2: the emerging role in hormone-dependent cancers and epigenetics

RM Reese, MM Harrison, ET Alarid - Endocrinology, 2019 - academic.oup.com
In mammals, the grainyhead-like transcription factor (GRHL) family is composed of three
nuclear proteins that are responsible for driving epithelial cell fate: GRHL1, GRHL2, and …

[HTML][HTML] Suppressor gene GRHL1 is associated with prognosis in patients with oesophageal squamous cell carcinoma

M Li, Z Li, X Guan, Y Qin - Oncology Letters, 2019 - spandidos-publications.com
Grainyhead like transcription factor 1 (GRHL1) is among the key family genes encoding
transcription factors that serve important roles in inhibiting tumor cell clone growth …

Roles of Grainyhead-like transcription factors in cancer

SM Frisch, JC Farris, PM Pifer - Oncogene, 2017 - nature.com
The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1–3
(GRHL1, GRHL2 and GRHL3), are transcription factors implicated in wound healing …

[HTML][HTML] Grainyhead-like 2 as a double-edged sword in development and cancer

J He, C Feng, H Zhu, S Wu, P Jin… - American journal of …, 2020 - ncbi.nlm.nih.gov
Abstract Grainyhead-like 2 (GRHL2), one of the three homologs of Drosophila grainyhead,
contributes to epithelial morphogenesis and differentiation. Dysregulation of GRHL2 has …