Nanoparticle size-specific actin rearrangement and barrier dysfunction of endothelial cells

Y Liu, N Rogel, K Harada, L Jarett, CH Maiorana… - …, 2017 - Taylor & Francis
In this work, we evaluated the impact of gold nanoparticles on endothelial cell behavior and
function beyond the influence on cell viability. Five types of gold nanoparticles were studied …

Influence of shear stress and size on viability of endothelial cells exposed to gold nanoparticles

C Fede, G Albertin, L Petrelli, R De Caro… - Journal of Nanoparticle …, 2017 - Springer
Screening nanoparticle toxicity directly on cell culture can be a fast and cheap technique.
Nevertheless, to obtain results in accordance with those observed in live animals, the …

Gold nanoparticles disrupt actin organization and pulmonary endothelial barriers

WE Sinclair, HH Chang, A Dan, PJA Kenis… - Scientific reports, 2020 - nature.com
This study explored the impact of gold nanoparticles on the metabolic activity and
morphology of human pulmonary endothelial cell monolayers. We developed a gold …

Low-dose albumin-coated gold nanorods induce intercellular gaps on vascular endothelium by causing the contraction of cytoskeletal actin

Z Li, J Liu, K Ballard, C Liang, C Wang - Journal of Colloid and Interface …, 2023 - Elsevier
Cytotoxicity of nanoparticles, typically evaluated by biochemical-based assays, often
overlook the cellular biophysical properties such as cell morphology and cytoskeletal actin …

Evaluation of gold nanoparticles toxicity towards human endothelial cells under static and flow conditions

C Fede, I Fortunati, V Weber, N Rossetto, F Bertasi… - Microvascular …, 2015 - Elsevier
A new in vitro model system, adding advection and shear stress associated with a flowing
medium, is proposed for the investigation of nanoparticles uptake and toxicity towards …

Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability …

CH Li, MK Shyu, C Jhan, YW Cheng… - Toxicological …, 2015 - academic.oup.com
Abstract Gold nanoparticles (Au-NPs) are being increasingly used as constituents in
cosmetics, biosensors, bioimaging, photothermal therapy, and targeted drug delivery. This …

Endothelial barrier dysfunction induced by nanoparticle exposure through actin remodeling via caveolae/raft-regulated calcium signalling

Y Liu, E Yoo, C Han, GJ Mahler, AL Doiron - NanoImpact, 2018 - Elsevier
The rapid development of modern nanotechnology has resulted in nanomaterial being use
in nearly all applications of life, raising the potential risk of nanomaterial exposure alongside …

Polyvinylpyrrolidone-coated gold nanoparticles inhibit endothelial cell viability, proliferation, and ERK1/2 phosphorylation and reduce the magnitude of endothelial …

T Mohamed, S Matou-Nasri, A Farooq… - International journal …, 2017 - Taylor & Francis
Background Gold nanoparticles (AuNPs) demonstrate clinical potential for drug delivery and
imaging diagnostics. As AuNPs aggregate in physiological fluids, polymer-surface …

Gold nanoparticles compromise TNF-α-induced endothelial cell adhesion molecule expression through NF-κB and protein degradation pathways and reduce …

TH Lai, CH Chung, BH Chen, CF Hung… - Journal of …, 2016 - ingentaconnect.com
The aim of this study was to investigate the anti-inflammatory effects and mechanism of
action of the gold nanoparticles (AuNPs) on vascular injury. In vitro vascular endothelial cell …

Gold nanoparticle interactions with endothelial cells cultured under physiological conditions

C Freese, L Anspach, RC Deller, SJ Richards… - Biomaterials …, 2017 - pubs.rsc.org
PEGylated gold nanoparticles (AuNPs) have an extended circulation time after intravenous
injection in vivo and exhibit favorable properties for biosensing, diagnostic imaging, and …