The present study was planned to evaluate the toxic effects of ribavirin on the reproductive
parameters in the male Wistar rat. Rats (11–13 weeks old) were treated with 5 injections (ip) …

Ribavirin (1-β-d-ribofuranosyl-1, 2, 4, triazole-3 carboxamide) is a broad-spectrum antiviral
drug. This study was aimed to investigate the mutagenicity of ribavirin on germ cells by …

The results have gotten from this study was showed that all animals of two experiment
groups that inoculated with Ribavirin drug appeared change in the thickness of seminiferous …

Ribavirin (l-~-D-ribofuranosyl-l, 2, 4-triazole-3-Carboxamide) is a potent inhibitor of inosine
monophosphate dehydrogenase, used widely as an antiviral drug. Although it has been …

Mechanisms of cytotoxicity of an antiviral drug, ribavirin was studied in the rat bone marrow
and testis. Ribavirin at the dose levels of 20, 100 and 200 mg/kg was treated (ip) either as …

Effects of ribavirin on the structure of peritubular sheath (PS) of seminiferous tubules and on
testicular functions were studied. We found that ribavirin at a dose of 4 mg/kg/day for 4 …

ABSTRACT Ribavirin (1-β-D-ribofuranosyl-1, 2, 4-triazole-3-carboxamide) is a water-
soluble, guanosine nucleoside analog that mimics other purines, including inosine and …

Objective: To investigate the in vivomutagenic effects of ribavirin in mice. Methods: Mice
were injected (ip) 20, 100, or 200 mg/kg ribavirin (single exposure) for bone marrow …

Sofosbuvir is one of the crucial drugs used in the treatment of chronic hepatitis C virus (HCV)
in adults and children with compensated liver disease, including cirrhosis. It may be used …

In utero exposure to the antivirals acyclovir and ganciclovir has been reported to induce
gross structural defects in rat offspring. The present study investigated the effects of maternal …