Cryptococcus neoformans is the most lethal pathogen of the central nervous system. The
gold standard treatment of cryptococcosis, a combination of amphotericin B with 5 …

The human diseases caused by the fungal pathogens Cryptococcus neoformans and
Cryptococcus gattii are associated with high indices of mortality and toxic and/or cost …

Current therapeutic options for cryptococcal meningitis are limited by toxicity, global supply,
and emergence of resistance. There is an urgent need to develop additional antifungal …

The fungal pathogen Cryptococcus neoformans poses a major threat to
immunocompromised patients and is a leading killer of human immunodeficiency virus (HIV) …

Many infectious diseases disproportionately affect people in the developing world.
Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the …

Cryptococcus neoformans is an encapsulated fungus that causes cryptococcosis. Central
nervous system infection is the most common clinical presentation followed by pulmonary …

Cryptococcus neoformans (Cn) is the leading cause of fungal meningitis, a deadly disease
with limited therapeutic options. Dissemination to the central nervous system hinges on the …

New, more accessible therapies for cryptococcosis represent an unmet clinical need of
global importance. We took a repurposing approach to identify previously developed drugs …

Cryptococcosis is a common opportunistic infection in patients with advanced HIV infection
and may also affect immunocompetent patients. The available antifungal agents are few and …

Cryptococcus gattii and Cryptococcus neoformans are environmental fungi that cause
cryptococcosis, which is usually treated with amphotericin B and fluconazole. However …