Biochemical and morphological characteristics of selenite-induced apoptosis in human hepatoma Hep G2 cells

HA Celik, HH Aydin, R Deveci, E Terzioglu… - Biological trace element …, 2004 - Springer
Selenium is a cellular growth inhibitor in many mammary tumor cells. To comprehend the
mechanism for the selenium-induced cell death, we examined the effects of sodium selenite …

Sodium selenite‐induced oxidative stress and apoptosis in human hepatoma HepG2 cells

HM Shen, CF Yang, CN Ong - International journal of cancer, 1999 - Wiley Online Library
The mechanisms involved in the anti‐carcinogenic activity of selenium remain to be
elucidated. In the present study, we examined sodium selenite‐induced oxidative stress and …

Differential apoptotic response of human cancer cells to organoselenium compounds

M Suzuki, M Endo, F Shinohara, S Echigo… - Cancer chemotherapy …, 2010 - Springer
Abstract Purpose Selenium (Se) compounds are well known to inhibit cell proliferation and
induce cell death in human cancer cells. Respective chemical forms of Se are intracellularly …

Toxicity of nutritionally available selenium compounds in primary and transformed hepatocytes

M Weiller, M Latta, M Kresse, R Lucas, A Wendel - Toxicology, 2004 - Elsevier
The essential trace element selenium is also toxic at low doses. Since supplementation of
selenium is discussed as cancer prophylaxis, we investigated whether or not bioavailable …

Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells

C Jiang, Z Wang, H Ganther, J Lu - Cancer research, 2001 - AACR
Apoptosis induction may be a mechanism mediating the anticancer activity of selenium. Our
earlier work indicated that distinct cell death pathways are likely involved in apoptosis …

Differential sensitivity of various human tumour-derived cell types to apoptosis by organic derivatives of selenium

RJ Jariwalla, B Gangapurkar… - British journal of nutrition, 2008 - cambridge.org
Selenium is an important trace element with anti-cancer properties. In the present study, the
apoptosis-inducing effects of organic selenium derivatives, namely methyl-l-selenocysteine …

Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line

W Zhong, TD Oberley - Cancer research, 2001 - AACR
The effects of selenium exposure were studied in LNCaP human prostate cancer cells, and
this same cell line adapted to selenium over 6 months to compare acute versus chronic …

Comparative analysis of apoptosis induction by selenium compounds in human lymphoblastic leukemia MT-4 cells.

A Philchenkov, M Zavelevich… - Experimental …, 2007 - europepmc.org
Aim The precise mechanisms of apoptosis induced by various selenium compounds are not
well understood. Therefore, the apoptogenic activity of two inorganic selenium compounds …

Induction of apoptosis by sodium selenite in human acute promyelocytic leukemia NB4 cells: involvement of oxidative stress and mitochondria

J Li, L Zuo, T Shen, C Xu, Z Zhang - Journal of trace elements in medicine …, 2003 - Elsevier
The mechanisms involved in the anti-carcinogenic activity of selenium remained to be
elucidated. In the present study, we examined sodium selenite induced apoptosis and …

Apoptosis induced by selenium in human glioma cell lines

Z Zhu, M Kimura, Y Itokawa, T Aoki… - Biological trace element …, 1996 - Springer
Several studies have shown that selenium can inhibit tumorigenesis in tissues. However,
little is known about the mechanism and the effect of selenium on DNA, especially in brain …