Recombinant adeno-associated virus (rAAV) vectors are promising human gene transfer
vectors, because they mediate long-term gene expression in vivo. The vector DNA form …

Recombinant adenoviral (rAd) vectors are capable of mediating high-efficiency gene
transfer in vivo. Under conditions requiring systemic administration, however, the use of rAd …

Recombinant adeno-associated virus (rAAV) vectors have shown significant promise as
vehicles for in vivo gene transfer, particularly for transduction of organs composed primarily …

Recombinant adeno-associated virus (rAAV) vectors are considered promising for human
gene replacement because they facilitate stable expression of therapeutic proteins in …

Stringent control of gene expression in human gene therapy strategies is important for both
therapeutic and safety reasons. Replication-defective vectors derived from adenoviruses …

Use of adeno-associated virus (AAV) to transduce genes into skeletal muscles can be
associated with T-cell responses to viral capsid and/or to transgenic protein. Intramuscular …

Genetically modified mice are important models for evaluation of potential gene therapies for
human diseases. However, their small size often precludes the use of clinically feasible …

The major barrier to the clinical application of adenovirus gene therapy for diseases that
require stable transgene expression is the immunogenicity of recombinant adenovirus …

Recombinant human adenoviruses (hAd) have become widely used as tools to achieve
efficient gene transfer. However, successful application of hAd-derived vectors in clinical …

In vivo gene transfer is being considered in the systemic delivery of therapeutic proteins.
This report evaluates the use of AAV vectors administered into muscle to deliver …