Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways

Z Zhang, W Cui, G Li, S Yuan, D Xu… - Journal of Agricultural …, 2012 - ACS Publications
Baicalein, one of the major flavonoids found in Scutellaria baicalensis Georgi, displays
neuroprotective effects on experimental models of Parkinson's disease (PD) in vitro and in …

Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease

J Huang, X Zhang, X Yang, Q Yv, F Ye, S Chen… - Chemico-Biological …, 2024 - Elsevier
Baicalin, a potent anti-oxidative and anti-inflammatory flavonoid compound derived from
Scutellaria baicalensis, has emerged as a neuroprotective agent. However, the mechanisms …

Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro

X Mu, G He, Y Cheng, X Li, B Xu, G Du - Pharmacology Biochemistry and …, 2009 - Elsevier
Baicalein, a flavonoid obtained from the root of Chinese medicinal herb Scutellaria
baicalensis, has been shown to exert a protective effect on neurons against several …

[HTML][HTML] Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease

Q Song, S Peng, X Zhu - Neurotoxicology, 2021 - Elsevier
Baicalein, a major bioactive flavone constituent isolated from Scutellaria baicalensis Georgi,
has neuroprotective properties in several neurological disorders. Many studies suggest that …

Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells

HJ Lee, YH Noh, YS Kim, KY Kim, YH Chung… - European Journal of …, 2005 - Elsevier
It has been suggested that baicalein, a flavonoid obtained from the Scutellaria root, exerts a
protective role on neurons against several neuronal insults. However, the protective …

Baicalein protects C6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the Nrf2 signaling pathway

EO Choi, JW Jeong, C Park… - International …, 2016 - spandidos-publications.com
Baicalein, a flavonoid originally obtained from the roots of Scutellaria baicalensis Georgi,
has been reported to possess various biological properties. Although several studies have …

Baicalein exerts anti-neuroinflammatory effects to protect against rotenone-induced brain injury in rats

X Zhang, Y Yang, L Du, W Zhang, G Du - International …, 2017 - Elsevier
Baicalein, a major bioactive flavone constituent isolated from Scutellaria baicalensis Georgi,
has been shown to be neuroprotective in several Parkinson's disease (PD) animal models …

Fucoxanthin prevents 6‐OHDA‐induced neurotoxicity by targeting Keap1

W Wu, H Han, J Liu, M Tang, X Wu… - Oxidative Medicine …, 2021 - Wiley Online Library
As the most abundant marine carotenoid extracted from seaweeds, fucoxanthin (FUC) is
considered to have excellent neuroprotective activity. However, the target of FUC for its …

Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-κB pathway, activation Nrf2 …

X Li, X Qin, J Tian, X Gao, X Wu, G Du… - Food and Chemical …, 2020 - Elsevier
Liquiritin, a flavone derived from the medicine food homology plant liquorice, possesses
neuroprotective. However, the neuroprotective mechanism is not clear. In this study …

Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria

X Li, G He, X Mu, B Xu, S Tian, X Yu, F Meng… - European journal of …, 2012 - Elsevier
Baicalein is one of the major flavonoids obtained from the Scutellaria root. Previous
pharmacological studies found that baicalein had neuroprotective effects in animal models …