Amyloids are a class of insoluble proteinaceous substances generally composed of linear
un-branched fibrils that are formed from misfolded proteins. Conformational diseases such …

Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

Protein crucial function and flexibility directly depend on its whole structure which is
determined by the native distribution of structural elements. Any disturbances in a protein …

Several human neurodegenerative diseases such as Alzheimer's disease, Parkinson's
disease and Familial Amyloidotic Polyneuropathy, have long been associated with …

Amyloidosis comprises a group of systemic and localized diseases with varied clinical
presentations. In these diseases, amyloid forms when proteins with a largely α-helical …

Protein glycation, also known as nonenzymatic glycosylation, is a spontaneous post-
translational modification that would change the structure and stability of proteins or …

Neurodegenerative diseases are associated with misfolding and deposition of specific
proteins, either intra or extracellularly in the nervous system. Advanced glycation end …

Amyloidogenic diseases are characterised by the formation of amyloid aggregates inside or
outside the cell. Amyloid-associated human diseases include Alzheimer's disease …

The conversion of proteins from their soluble states into well-organized fibrillar aggregates is
associated with a wide range of pathological conditions, including neurodegenerative …

As the population is aging, the incidence of age-related neurodegenerative diseases, such
as Alzheimer and Parkinson disease, is growing. The pathology of neurodegenerative …