2 (±)-7, 8, 3′, 4′, 5′-pentamethoxyflavan induces G2/M phase arrest and apoptosis in HL60 cells

E Ma, Y Li, W Zhang, X Wang, W Tai, T Li, L Zhang… - Toxicology in Vitro, 2009 - Elsevier
2 (±)-7, 8, 3′, 4′, 5′-pentamethoxyflavan (PMF), a synthetic flavan racemate, showed
growth inhibitory effect on various kinds of tumor cells. The present study is to investigate the …

[HTML][HTML] Xianlinglianxiafang inhibited the growth and metastasis of triple-negative breast cancer via activating PPARγ/AMPK signaling pathway

X Yang, R Yang, Y Zhang, Y Shi, M Ma, F Li… - Biomedicine & …, 2023 - Elsevier
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer
characterized by high invasion and metastasis rates. Xian-Ling-Lian-Xia formula (XLLX) is a …

[HTML][HTML] A novel derivative of curcumol, HCL-23, inhibits the malignant phenotype of triple-negative breast cancer and induces apoptosis and HO-1-dependent …

P Zhao, H Song, F Gao, L Chen, J Qiu, J Jin, C Pan… - Molecules, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast
cancer. Curcumol, as a natural small molecule compound, has potential anti-breast cancer …

Flubendazole elicits anti‐metastatic effects in triple‐negative breast cancer via STAT3 inhibition

E Oh, YJ Kim, H An, D Sung, TM Cho… - … journal of cancer, 2018 - Wiley Online Library
Tumor metastasis remains the cause of 90% of cancer‐related deaths. Cancer stem cells
(CSC) are thought to be responsible for the aggressive and metastatic nature of triple …

Discovery of novel G9a/GLP covalent inhibitors for the treatment of triple-negative breast cancer

Q Zhang, B Chang, Q Feng, L Li - European Journal of Medicinal Chemistry, 2023 - Elsevier
Triple-negative breast cancer (TNBC) has become a serious threat to women's health.
Research on epigenetic drugs is gradually deepening and is expected to provide new …

[HTML][HTML] Identification of triptonide as a therapeutic agent for triple negative breast cancer treatment

B Gao, J Chen, B Han, X Zhang, J Hao, AE Giuliano… - Scientific Reports, 2021 - nature.com
Triple-negative breast cancer (TNBC) is associated with a high rate of early recurrence and
distant metastasis, frequent development of therapeutic resistance, and a poor prognosis …

Featured Article: Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells

O Huang, W Zhang, Q Zhi, X Xue… - Experimental …, 2015 - journals.sagepub.com
Triple-negative breast cancer (TNBC) is defined as a group of primary breast cancers
lacking expression of estrogen, progesterone, and human epidermal growth factor receptor …

Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer

Q Zhang, G Sun, Y Huang, S Cui, T Li, L Zhao… - European Journal of …, 2023 - Elsevier
Triple negative breast cancer (TNBC) is considered to be the most difficult subtype of breast
cancer to treat because of its extremely prone to metastasis and the lack of targeted therapy …

Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD‐L1 in MDA‐MB‐231 Triple‐Negative Breast Cancer Cells

G Adinew, SS Messeha, R Badisa, E Taka… - The FASEB …, 2022 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a
metastatic nature. TNBC lacks the expression of the progesterone receptor, estrogen …

Multipathway regulation induced by 4‐(phenylsulfonyl) morpholine derivatives against triple‐negative breast cancer

FW Yang, TL Mai, YCJ Lin, YC Chen… - Archiv der …, 2024 - Wiley Online Library
Phenotypic drug discovery (PDD) is an effective drug discovery approach by observation of
therapeutic effects on disease phenotypes, especially in complex disease systems. Triple …