Impact of transient hypotension on regional cerebral blood flow in humans

NCS Lewis, KJ Smith, AR Bain, KW Wildfong… - Clinical …, 2015 - portlandpress.com
We examined the impact of progressive hypotension with and without hypocapnia on
regional extracranial cerebral blood flow (CBF) and intracranial velocities. Participants …

Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity

NCS Lewis, L Messinger… - Journal of applied …, 2014 - journals.physiology.org
We examined 1) whether global cerebral blood flow (CBF) would increase across a 6-h bout
of normobaric poikilocapnic hypoxia and be mediated by a larger increase in blood flow in …

Characterization of cerebral macro-and microvascular hemodynamics during transient hypotension

LN Shoemaker, D Milej, A Sajid… - Journal of Applied …, 2023 - journals.physiology.org
The aim of the current study was to establish the interplay between blood flow patterns
within a large cerebral artery and a downstream microvascular segment under conditions of …

Cerebrovascular dynamics of autoregulation and hypoperfusion: an MRI study of CBF and changes in total and microvascular cerebral blood volume during …

G Zaharchuk, JB Mandeville, AA Bogdanov Jr… - Stroke, 1999 - Am Heart Assoc
Background and Purpose—To determine how cerebral blood flow (CBF), total and
microvascular cerebral blood volume (CBV), and blood oxygenation level–dependent …

Cerebral blood flow velocity underestimates cerebral blood flow during modest hypercapnia and hypocapnia

NS Coverdale, JS Gati, O Opalevych… - Journal of applied …, 2014 - journals.physiology.org
To establish the accuracy of transcranial Doppler ultrasound (TCD) measures of middle
cerebral artery (MCA) cerebral blood flow velocity (CBFV) as a surrogate of cerebral blood …

Cerebral blood flow response to simulated hypovolemia in essential hypertension: a magnetic resonance imaging study

S Neumann, AE Burchell, JCL Rodrigues… - …, 2019 - Am Heart Assoc
Hypertension is associated with raised cerebral vascular resistance and cerebrovascular
remodeling. It is currently unclear whether the cerebral circulation can maintain cerebral …

Induced response to hypercapnia in the two-compartment total cerebral blood volume: influence on brain vascular reserve and flow efficiency

A Keyeux… - Journal of Cerebral …, 1995 - journals.sagepub.com
This study was undertaken to investigate the mechanisms of CBF increase as induced by
hypercapnia. It was achieved in anesthetized rats by determining total cerebral blood …

The role of cerebral oxygenation and regional cerebral blood flow on tolerance to central hypovolemia

VL Kay, CA Rickards - American Journal of Physiology …, 2016 - journals.physiology.org
Tolerance to central hypovolemia is highly variable, and accumulating evidence suggests
that protection of anterior cerebral blood flow (CBF) is not an underlying mechanism. We …

Impact of age on cerebrovascular dilation versus reactivity to hypercapnia

NS Coverdale, MB Badrov… - Journal of Cerebral …, 2017 - journals.sagepub.com
This study quantified the effect of age on cerebrovascular reactivity and cerebrovascular
conductance while accounting for differences in grey matter volume in younger (YA: n= 12; …

The effect of hypercapnia on static cerebral autoregulation

BG Perry, SJE Lucas, KN Thomas… - Physiological …, 2014 - Wiley Online Library
Hypercapnia impairs cerebrovascular control during rapid changes in blood pressure (BP);
however, data concerning the effect of hypercapnia on steady state, nonpharmacological …