Inflammatory rheumatic diseases (IRD) are complex disorders characterized by chronic
inflammation of the joints and related skeletal structures. The most common forms of IRD are …

Along with its capacity to store energy, the white adipose tissue is a source of cytokines,
called “adipocytokines” or “adipokines”, acting by paracrine, autocrine and systemic …

In the last two decades we have witnessed a boost in scientific interest and knowledge of
adipose tissue biology to such an extent that it was promoted to an active endocrine organ …

We performed a systematic literature review to summarize the underlying pathogenic
mechanisms by which adipokines influence rheumatological diseases and the resulting …

Adipose tissue is ubiquitously present in the human organism. It is a structural component of
many organs including the skin, the intestinal tract, and the joints. Besides its central function …

Adipokines are proteins produced by white adipose tissue, which is an active secretory
organ. Regulation of immune and inflammatory responses is among the multiple …

Osteoarthritis (OA) is a most common multifactorial degenerative joint disease in elderly
individuals. OA is affecting severely the quality of life of patients, while the causes of OA are …

Rheumatic diseases encompass a diverse group of chronic disorders that commonly affect
musculoskeletal structures. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two …

Inflammation is a complex mechanism of cell/tissue responses to injuries triggered by
multiple causes, including trauma, pathogens or autoimmune abnormal responses. In the …

Rheumatoid arthritis affects millions of people worldwide and is considered a chronic
multisystem disease whose causes are unknown. In general, the main objective of …