N, 2, 6-Trisubstituted 1 H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in silico …

EC Pham, TV Le Thi, HHL Hong, BNV Thi, LB Vong… - RSC …, 2023 - pubs.rsc.org
Compounds containing benzimidazole moiety occupy privileged chemical space for
discovering new bioactive substances. In continuation of our recent work, 69 benzimidazole …

Design, synthesis, bio-evaluation, and in silico studies of some N-substituted 6-(chloro/nitro)-1 H-benzimidazole derivatives as antimicrobial and anticancer agents

EC Pham, TVT Le, TN Truong - RSC advances, 2022 - pubs.rsc.org
A new series of 6-substituted 1H-benzimidazole derivatives were synthesized by reacting
various substituted aromatic aldehydes with 4-nitro-o-phenylenediamine and 4-chloro-o …

Synthetic approach to potential anticancer benzimidazole derivatives: a review

R Kumar, C Singh, A Mazumder… - Mini Reviews in …, 2022 - ingentaconnect.com
Cancer is one of the deadliest diseases in many developed and developing countries.
Continuous efforts are required for designing better therapeutic agents for the treatment of …

[HTML][HTML] Structure-based design of functionalized 2-substituted and 1, 2-disubstituted benzimidazole derivatives and their in vitro antibacterial efficacy

OO Ajani, OO Tolu-Bolaji, SJ Olorunshola… - Journal of advanced …, 2017 - Elsevier
The aim of this present study was to synthesize 2-substituted and 1, 2-disubstituted
benzimidazole derivatives to investigate their antibacterial diversity for possible future drug …

Synthesis and biological profile of substituted benzimidazoles

N Vashist, SS Sambi, B Narasimhan, S Kumar… - Chemistry Central …, 2018 - Springer
Background A series of benzimidazole derivatives was developed and its chemical scaffolds
were authenticated by NMR, IR, elemental analyses and physicochemical properties. The …

Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents

S Tahlan, S Kumar, K Ramasamy, SM Lim, SAA Shah… - BMC chemistry, 2019 - Springer
Background Nitrogen containing heterocycles are widely used and investigated by
pharmaceutical industry, as they are important in discovery and designing of new drug …

A review on the modern synthetic approach of benzimidazole candidate

M Faheem, A Rathaur, A Pandey… - …, 2020 - Wiley Online Library
Benzimidazole structure contains imidazole ring fused with phenyl ring at 4‐and 5‐position.
The mono and disubstituted derivatives of benzimidazole are very interesting heterocyclic …

Design, synthesis, SAR study, antimicrobial and anticancer evaluation of novel 2-mercaptobenzimidazole azomethine derivatives

S Tahlan, B Narasimhan, SM Lim… - mini reviews in …, 2020 - ingentaconnect.com
Background: Various analogues of benzimidazole are found to be biologically and
therapeutically potent against several ailments. Benzimidazole when attached with …

The design and synthesis of potent benzimidazole derivatives via scaffold hybridization and evaluating their antiproliferative and proapoptotic activity against breast …

MS Elgawish, MS Nafie, ASA Yassen… - New Journal of …, 2022 - pubs.rsc.org
One of the current approaches used in drug discovery and development is the synthesis of
novel small compounds from existing structural motifs via molecular hybridization. In the …

A facile and efficient synthesis of benzimidazole as potential anticancer agents

TKC Huynh, THA Nguyen, NHS Tran… - Journal of Chemical …, 2020 - Springer
This study reports a simple process to synthesize and separate of 2-(substituted-phenyl)
benzimidazole derivatives with high yield and efficiency. Specifically, by reacting ortho …