N, 2, 6-Trisubstituted 1 H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in silico …
Compounds containing benzimidazole moiety occupy privileged chemical space for
discovering new bioactive substances. In continuation of our recent work, 69 benzimidazole …
discovering new bioactive substances. In continuation of our recent work, 69 benzimidazole …
Design, synthesis, bio-evaluation, and in silico studies of some N-substituted 6-(chloro/nitro)-1 H-benzimidazole derivatives as antimicrobial and anticancer agents
A new series of 6-substituted 1H-benzimidazole derivatives were synthesized by reacting
various substituted aromatic aldehydes with 4-nitro-o-phenylenediamine and 4-chloro-o …
various substituted aromatic aldehydes with 4-nitro-o-phenylenediamine and 4-chloro-o …
Synthetic approach to potential anticancer benzimidazole derivatives: a review
R Kumar, C Singh, A Mazumder… - Mini Reviews in …, 2022 - ingentaconnect.com
Cancer is one of the deadliest diseases in many developed and developing countries.
Continuous efforts are required for designing better therapeutic agents for the treatment of …
Continuous efforts are required for designing better therapeutic agents for the treatment of …
[HTML][HTML] Structure-based design of functionalized 2-substituted and 1, 2-disubstituted benzimidazole derivatives and their in vitro antibacterial efficacy
OO Ajani, OO Tolu-Bolaji, SJ Olorunshola… - Journal of advanced …, 2017 - Elsevier
The aim of this present study was to synthesize 2-substituted and 1, 2-disubstituted
benzimidazole derivatives to investigate their antibacterial diversity for possible future drug …
benzimidazole derivatives to investigate their antibacterial diversity for possible future drug …
Synthesis and biological profile of substituted benzimidazoles
N Vashist, SS Sambi, B Narasimhan, S Kumar… - Chemistry Central …, 2018 - Springer
Background A series of benzimidazole derivatives was developed and its chemical scaffolds
were authenticated by NMR, IR, elemental analyses and physicochemical properties. The …
were authenticated by NMR, IR, elemental analyses and physicochemical properties. The …
Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents
Background Nitrogen containing heterocycles are widely used and investigated by
pharmaceutical industry, as they are important in discovery and designing of new drug …
pharmaceutical industry, as they are important in discovery and designing of new drug …
A review on the modern synthetic approach of benzimidazole candidate
M Faheem, A Rathaur, A Pandey… - …, 2020 - Wiley Online Library
Benzimidazole structure contains imidazole ring fused with phenyl ring at 4‐and 5‐position.
The mono and disubstituted derivatives of benzimidazole are very interesting heterocyclic …
The mono and disubstituted derivatives of benzimidazole are very interesting heterocyclic …
Design, synthesis, SAR study, antimicrobial and anticancer evaluation of novel 2-mercaptobenzimidazole azomethine derivatives
S Tahlan, B Narasimhan, SM Lim… - mini reviews in …, 2020 - ingentaconnect.com
Background: Various analogues of benzimidazole are found to be biologically and
therapeutically potent against several ailments. Benzimidazole when attached with …
therapeutically potent against several ailments. Benzimidazole when attached with …
The design and synthesis of potent benzimidazole derivatives via scaffold hybridization and evaluating their antiproliferative and proapoptotic activity against breast …
One of the current approaches used in drug discovery and development is the synthesis of
novel small compounds from existing structural motifs via molecular hybridization. In the …
novel small compounds from existing structural motifs via molecular hybridization. In the …
A facile and efficient synthesis of benzimidazole as potential anticancer agents
TKC Huynh, THA Nguyen, NHS Tran… - Journal of Chemical …, 2020 - Springer
This study reports a simple process to synthesize and separate of 2-(substituted-phenyl)
benzimidazole derivatives with high yield and efficiency. Specifically, by reacting ortho …
benzimidazole derivatives with high yield and efficiency. Specifically, by reacting ortho …
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