Background It remains unclear regarding the contribution of each individual symptom in
predicting the outcome in major depressive disorder (MDD). The objective of this analysis …

Major depressive disorder (MDD) is an illness of great morbidity that affects many people
across the world. The current goal for treatment of MDD is to achieve remission (ie, no …

This study compared the stabilized duloxetine dose through approximately 12 weeks of
treatment in patients initiating duloxetine therapy with that in patients switching to duloxetine …

BACKGROUND: It is uncertain as to what short-term outcomes predict long-term treatment
compliance and outcomes in patients with MDD. AIMS: To determine what treatment …

Background Duloxetine and venlafaxine extended release (venlafaxine XR) are SNRIs
indicated for the treatment of MDD. This study addresses whether duloxetine and …

Continuation of antidepressant therapy after patients have responded to medication has
been shown to greatly reduce but not eliminate relapse. We evaluated response to …

Objectives. To explore the effect of pain symptoms and improvements in pain on depression
outcomes. Methods. We analyzed data from A Randomized Trial Investigating SSRI …

Background: It is unknown whether depressed patients who have experienced intolerable
side effects to one antidepressant can safely and effectively be switched to a second …

The present overview investigates whether different antidepressants have differing
discontinuation symptoms upon treatment cessation, if these symptoms vary between …

Background Response to antidepressants in major depressive disorder is variable and
determinants are not well understood or used to design clinical trials. We aimed to …