Background Hypoxic perinatal brain injury is caused by lack of oxygen to baby's brain and
can lead to death or permanent brain damage. However, the effectiveness of therapeutic …

Background The objective of this study was to systematically review randomized trials
assessing therapeutic hypothermia as a treatment for term neonates with hypoxic ischemic …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Context: Therapeutic hypothermia is the recommended treatment for neonates with
moderate or severe hypoxic ischemic encephalopathy (HIE). There is an increasing trend to …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

Objectives To systematically review the effectiveness, as determined by survival without
moderate to severe neurodevelopmental disability in infancy and childhood, and the safety …

Objective To establish the evidence of therapeutic hypothermia for newborns with hypoxic
ischemic encephalopathy (HIE). Data Sources Cochrane Central Register of Controlled …

Background Therapeutic hypothermia (TH) is regarded as the most efficacious therapy for
neonatal hypoxic encephalopathy. However, limitations in previous systematic reviews and …

Objective To determine whether moderate hypothermia after hypoxic-ischaemic
encephalopathy in neonates improves survival and neurological outcome at 18 months of …

OBJECTIVE: To investigate the efficacy and safety of selective head cooling with mild
systemic hypothermia in hypoxic-ischemic encephalopathy (HIE) in newborn infants. STUDY …